磁共振FACT序列脂肪定量技术对2型糖尿病患者腰椎及椎旁肌肉脂肪含量的定量研究

Quantitative study on fat content of lumbar spine and paravertebral muscles in patients with type 2 diabetes mellitus by magnetic resonance FACT sequence fat quantification technique

目的采用磁共振脂肪定量(fat analysis&calculation technique,FACT)序列脂肪定量技术,分析2型糖尿病(type 2 diabetes mellitus,T2DM)患者腰椎椎体及椎旁肌肉的脂肪分数(fat fraction,FF),探讨T2DM患者腰椎椎体、椎旁肌肉内脂肪含量的变化及其相关性。方法选取31例T2DM患者和同期31例健康对照者(与T2DM患者年龄、性别、女性绝经情况、体质量指数进行配对),均行磁共振FACT序列扫描,分别测量腰3椎体及腰3/4椎间盘水平椎旁肌的FF值,利用独立样本t检验对糖尿病组及对照组的腰椎椎体及椎旁肌的脂肪含量进行统计分析,采用Spearman/Pearson相关系数分别对T2DM组、对照组患者腰椎椎体及椎旁肌FF进行相关性分析。结果T2DM组腰椎椎体及椎旁肌肉FF值均高于正常对照组,差异均有统计学意义(P<0.05);T2DM组腰椎椎体与椎旁肌FF值无相关性(P>0.05),对照组腰椎椎体与左侧竖脊肌FF值无相关性(P>0.05);对照组腰椎椎体与左侧多裂肌、右侧竖脊肌、右侧多裂肌FF值呈正相关(P<0.05)。结论磁共振FACT序列脂肪定量技术可以用于评价T2DM患者腰椎椎体及椎旁肌肉脂肪含量;T2DM患者腰椎及椎旁肌的脂肪含量较健康人群产生变化,脂肪沉积更明显;与健康人群不同,T2DM患者腰椎与椎旁肌的脂肪含量之间无相关性。

Objective:To analyze t fat fraction(FF)of lumbar vertebral body and paravertebral muscle in patients with type 2 diabetes mellitus(T2DM)by magnetic resonance imaging(MRI)FACT sequence fat quantification technique,and to explore changes and correlation of fat content of lumbar vertebral body and paravertebral muscle in T2DM patients.Methods:Thirty-one T2DM patients and twenty-six age-,sex-,menopausal status-,and body mass index-matched healthy controls were chosen.All subjects underwent sagittal and transverse MRI FACT sequence scanning,and the FF values of paraspinal muscles at the level of lumbar 3 and lumbar 3/4 intervertebral discs were measured.Independent sample t test was used to analyze the fat content of lumbar vertebral body and paraspinal muscle in the diabetic group and the control group.Spearman correlation coefficient and Pearson correlation coefficient were conducted to analyze the correlation between the two variables in the T2DM group and the control group.Results:The FF values of lumbar vertebral body and paravertebral muscles in T2DM group were higher than those in normal control group,and the differences were statistically significant(P<0.05).There was no correlation between the FF value of lumbar vertebral body and paraspinal muscle in T2DM group(P>0.05),and there was no correlation between the FF value of lumbar vertebral body and left erector spinae muscle in control group(P>0.05).In the control group,the FF values of lumbar vertebral body and other paraspinal muscles were positively correlated(P<0.05).Conclusion:FACT sequence fat quantification technique can be used to evaluate the fat content of lumbar vertebral body and paravertebral muscle in patients with T2DM.Compared with the healthy,the fat content of lumbar spine and paraspinal muscles in T2DM patients have changed,and the fat deposition is more obvious.There is no significant relationship between lumbar and paraspinal muscle fat content in T2DM patients.