血清CA125、β-HCG、P检测在早期异位妊娠诊断中的价值分析

Value analysis of serum CA125,β-HCG,P in diagnosis of early ectopic pregnancy

目的探讨血清糖链抗原-125(carbohydrate antigen 125,CA-125)、游离β亚单位人绒毛膜促性腺激素(B-HCG)、孕酮(progesterone,P)在早期异位妊娠(ectopic pregnancy,EP)诊断中的应用价值。方法选取45例EP患者EP组,选取45例同期正常妊娠孕妇为对照组,比较两组血清CA125、β-HCG和P水平,采用受试者工作特征曲线(ROC)评估3项指标诊断早期异位妊娠的价值。结果EP组血清CA-125、β-HCG、P水平均低于对照组(P<0.05);血清CA-125、β-HCG和P对早期异位妊娠诊断的最佳临界值分别为41U/mL、14304mIU/mL、18.34ng/mL,ROC曲线下面积分别为0.902、0.886、0.896。结论血清CA-125、β-HCG和P水平的测定对EP和早期正常宫内妊娠的鉴别诊断有一定价值,开展CA-125、β-HCG和P水平的检测很有必要,值得临床推广与应用。

Objective To investigate serum carbohydrate antigen 125(CA-125),free beta subunit human chorionic gonadotropin(β-HCG),progesterone(progesterone),carbohydrate antigen 125(CA-125),free beta subunit human chorionic gonadotropin(progesterone),carbohydrate antigen 125(CA-125),free beta subunit human chorionic gonadotropin(HCG),carbohydrate antigen 125(CA-125)PThe application value in the diagnosis of early ectopic pregnancy(EP).Methods A total of 45 EP patients in the EP group and 45 normal pregnant women in the same period were selected as the control group.Serum levels of CA125,β-HCG and P were compared between the two groups.Receiver operating characteristic curve(ROC)was used to evaluate the value of 3 indicators in diagnosing early ectopic pregnancy.Results The levels of CA-125,β-HCG and P in EP group were lower than those in control group(P<0.05).The optimal cutoff values of serum CA-125,β-HCG and P for the diagnosis of early ectopic pregnancy were 41 U/mL,14304 mIU/mL and 18.34 ng/mL,respectively,and the area under ROC curve were 0.902,0.886 and 0.896,respectively.Conclusion The determination of serum CA-125,β-HCG and P levels is valuable for the differential diagnosis of EP and early normal intrauterine pregnancy.It is necessary to carry out the detection of CA-125,β-HCG and P levels,which is worthy of clinical promotion and application.