NICU患儿用动脉血代替足跟血进行新生儿代谢病筛查的可行性探讨

Feasibility of Using Arterial Blood Instead of Heel Stick Blood for Newborn Metablic Screening in NICU

目的新生儿重症监护病房(NICU)患儿中早产及低出生体重新生儿占相当比重,采集足跟血制做干血片进行新生儿遗传代谢病筛查有一定困难,同时所有NICU患儿常规采集动脉血进行其它化验检查,因此有应用残余动脉血替代足跟血进行新筛项目检测的实际需求。本研究主要目的为探讨可否应用动脉血替代足跟血进行新生儿代谢病筛查。方法选择我院NICU患儿1436名,同时利用动脉血与足跟血制做干血片,检测患儿苯丙氨酸及促甲状腺素水平。结果经过统计学分析,发现应用动脉血和足跟血制做的干血片进行新生儿代谢病筛查,结果有显著差异。结论对于NICU患儿,不能简单的应用动脉血替代足跟血进行新生儿代谢病筛查,而应建立动脉血自己的切值,以方便NICU患儿进行新生儿代谢病筛查。

Objective The children in Neonatal Intensive Care Unit(NICU)are often preterm birth and at low birth weight.It is difficult to collect their heel stick blood to make dried blood spots for newborn metablic screening.At the same time all the children in NICU will do other routine test with arterial blood,hence there is need for NICU substitute heel stick blood with residual arterial blood.The purpose of this study was to investigate whether arterial blood could be used to replace heel blood in newborn metablic screening.Methods 1436 children in NICU in our hospital were selected.At the same time,arterial blood and heel stick blood were used to make dried blood spots.The levels of phenylalanine and thyrotropin were detected.Results After statistical analysis,it was found that there were significant differences in the results of new screening items between arterial blood and heel stick blood.Conclusion For children in NICU,arterial blood should not used to replace heel stick blood for the newborn metablic screening,but its own cut off value should be established.