新生儿朗格汉斯细胞组织细胞增生症一例

Neonatal Langerhans cell histiocytosis:a case report

患儿,女,27天,生后半月出现皮疹、发热、肝脾肿大、贫血、血小板减少、消化道出血等表现,经皮肤活检病理及免疫组化最终诊断为新生儿多系统朗格汉斯细胞组织细胞增生症。给予泼尼松、长春新碱化疗,成功挽救患儿。随诊至患儿11月龄,体重增加良好、食纳可,多次查血常规及肝肾功能等指标无异常,病情稳定。

A 27-day-old infant presented with rash,fever,hepatosplenomegaly,anemia,thrombocytopenia,and gastrointestinal bleeding in the postnatal half a month.According the features of skin biopsy and immunohistochemistry,the final diagnosis was neonatal multi-system Langerhans cell histiocytosis.The patient was successfully treated with chemotherapy of prednisone and vincristine actively.Follow up until 11 months old,good weight gain and appetite,multiple blood tests,liver and kidney function indicators are normal,and the condition is stable.