丹红注射液联合丁苯酞注射液治疗急性脑梗死患者的临床效果及对氧化应激的影响

Clinical effect of Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction and its influence on oxidative stress

目的 分析丹红注射液联合丁苯酞注射液治疗急性脑梗死患者的临床效果及对氧化应激的影响。方法 将我院2020年12月至2022年12月收治的64例急性脑梗死患者以治疗方案不同分为常规组和观察组,每组32例。常规组在基础治疗基础上给予丁苯酞注射液治疗,观察组在常规组治疗基础上增加丹红注射液治疗。比较两组的治疗效果。结果 观察组的治疗总有效率显著高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、S100-β蛋白、8-羟基脱氧鸟苷(8-OHdG)及丙二醛(MDA)水平显著低于常规组,超氧化物歧化酶(SOD)、总抗氧化能力(T-AOC)及谷胱甘肽(GSH)水平显著高于常规组,差异具有统计学意义(P<0.05)。治疗后,观察组基底动脉的最大血流速度(Vmax)、最小血流速度(Vmin)及平均血流量(Qmean)显著高于常规组,外周阻力(RV)显著低于常规组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论 丹红注射液联合丁苯酞注射液治疗急性脑梗死患者可取得安全高效的临床效果,并改善氧化应激反应。

Objective To analyze the clinical effect of Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction and its influence on oxidative stress.Methods Sixty-four patients with acute cerebral infarction admitted in our hospital from December 2020 to December 2022 were divided into routine group and observation group according to the different treatment plan,with 32 cases in each group.The routine group was treated with butylphthalide injection on the basis of basic treatment,and the observation group was treated with Danhong injection on the basis of the routine group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the routine group,and the difference was statistically significant(P<0.05).After treatment,the levels of neuron-specific enolase(NSE),S100-βprotein,8-hydroxydeoxyguanosine(8-OHdG)and malondialdehyde(MDA)in the observation group were significantly lower than those in the routine group,the levels of superoxide dismutase(SOD),total antioxidant capacity(T-AOC)and glutathione(GSH)were significantly higher than those in the routine group,and the differences were statistically significant(P<0.05).After treatment,the maximum blood flow velocity(Vmax),minimum blood flow velocity(Vmin)and mean blood flow(Qmean)of the basilar artery in the observation group were significantly higher than those in the routine group,and the peripheral resistance(RV)was significantly lower than that in the routine group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Danhong injection combined with butylphthalide injection in the treatment of patients with acute cerebral infarction can achieve safe and efficient clinical effect,and improve oxidative stress response.