牛呼吸道合胞体病毒G和F蛋白的生物学功能

Biological Functions of Bovine Respiratory Syncytial Virus G and F Proteins

牛呼吸道合胞体病毒(bovine respiratory syncytial virus, BRSV)是一种在世界范围内引起牛呼吸道疾病的病毒性病因之一,主要引起1岁龄以下犊牛的严重下呼吸道感染。BRSV共编码9种结构蛋白,其中附着蛋白(G蛋白)和融合蛋白(F蛋白)是BRSV表面主要的包膜糖蛋白,参与病毒吸附、融合宿主细胞的过程。G和F蛋白含多种识别表位,能够刺激机体产生中和抗体反应,常常是牛呼吸道合胞体病(bovine respiratory syncytial disease, BRSD)疫苗开发所关注的重点。探究G和F蛋白在BRSV侵染中的作用机理对于病毒致病机理分析、疫苗开发具有重要意义。本文旨在对牛呼吸道合胞体病毒G和F蛋白的结构功能及有关疫苗的开发加以综述,以期为BRSV疫苗的研制和BRSD的防控提供参考。

Bovine respiratory syncytial virus(BRSV)is one of the viral causes of bovine respiratory diseases worldwide,mainly causing severe lower respiratory tract infections in calves under 1 year of age.BRSV encodes a total of 9 structural proteins,among which attachment protein(G protein)and fusion protein(F protein)are the main envelope glycoproteins on the surface of BRSV,which participate in the process of viral adsorption and fusion of host cells.G and F proteins contain a variety of identifying epitopes that stimulate the body′s production of neutralizing antibody responses and are often the focus of vaccine development for Bovine respiratory syncytial disease(BRSD).Exploring the mechanism of G and F proteins in BRSV infection is of great significance for the analysis of viral pathogenesis and vaccine development.This article aims to review the structural functions of BRSV ovine respiratory syncytial virus G and F proteins and the development of related vaccines,in order to provide reference for the development of BRSV vaccine and the prevention and control of BRSD.