基于多模态磁共振成像探讨针刺治疗卒中后失语症的研究进展

Research progress of acupuncture in the treatment of post-stroke aphasia based on multimodal magnetic resonance imaging

卒中后失语症(post-stroke aphasia,PSA)是指因脑血管或言语中枢神经功能紊乱引起的后天性语言功能障碍。针刺治疗PSA已取得较好的临床疗效,但其作用机制尚未明确。近年来,多模态MRI飞速发展,此项技术具有无辐射、多参数、多序列成像等优点,已被众多学者应用于PSA中枢效应机制研究。本研究基于功能MRI、弥散张量成像、结构性MRI、磁共振波谱成像等多模态成像技术,从脑功能、脑结构及脑代谢等角度探讨了针刺对PSA患者中枢效应机制,旨在为针刺治疗PSA临床个体化诊疗方案提供新方向,为研究针刺治疗PSA的潜在机制提供新思路。

Post-stroke aphasia refers to acquired language disorder caused by cerebrovascular or speech central nervous system disorders,which is manifested as language dysfunction.Acupuncture has achieved good clinical efficacy in the treatment of post-stroke aphasia,but its mechanism remains to be explored.In recent years,with the rapid development of multimodal MRI,this technology has the advantages of non-radiation,multi-parameter,multi-sequence imaging,and has been used by many scholars to study the central effect mechanism of PSA.Based on multimodal imaging techniques such as functional MRI,diffusion tensor imaging,structural MRI and magnetic resonance spectroscopy,this study explores the central effect mechanism of acupuncture on PSA patients from the perspective of brain function,brain structure and brain metabolism,aiming to provide a new direction for the clinical individualized diagnosis and treatment of PSA treated with acupuncture.It provides new ideas for studying the potential mechanism of acupuncture in the treatment of post-stroke aphasia.