血液灌流对急性有机磷中毒的治疗效果分析

Analysis of therapeutic effect of hemoperfusion on acute organophosphorus poisoning

目的:观察血液灌流治疗急性有机磷中毒患者的临床疗效。方法:回顾性分析2021年3月至2022年12月期间本院急诊科收治急性有机磷中毒患者123例的临床资料。依据治疗方式不同将患者分为对照组(n=59,常规治疗)和观察组(n=64,血液灌流治疗)。分析比较两组治疗情况、血清指标[胆碱酯酶(Cholinesterase,CHE)、白介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)]及并发症发生率。结果:治疗后,观察组苏醒时长、呼吸机使用时长、意识恢复时长、住院天数均明显短于对照组,观察组服用阿托品总用剂量、病死率低于对照组,且治愈率高于对照组(P<0.05)。观察组CHE水平高于对照组,且观察组IL-6、CRP水平低于对照组(P<0.05)。观察组并发症发生率显著低于对照组(P<0.05)。结论:血液灌流治疗急性有机磷中毒患者的临床疗效得到显著提高,利于患者康复,提高CHE活性,且有效抑制炎症反应,缓解患者呼吸衰竭、肝损伤等症状。

Objective:To observe the clinical effect of hemoperfusion on patients with acute organophosphorus poisoning.Methods:The clinical data of 123 patients with acute organophosphorus poisoning treated in the emergency department of our hospital from March 2021 to December 2022 were retrospectively analyzed.Patients were divided into control group(n=59,conventional treatment)and observation group(n=64,hemoperfusion treatment)according to different treatment methods.The treatment status,serum indexes(Cholinesterase(CHE),interleukin-6(IL-6),C-reactive protein(CRP))and complication rate of the two groups were analyzed and compared.Results:After treatment,the recovery time,ventilator use time,consciousness recovery time and hospitalization days in the observation group were significantly shorter than those in the control group,the total dose of atropine,the fatality rate and the cure rate in the observation group were lower than those in the control group(P<0.05).CHE level in observation group was higher than that in control group,IL-6 and CRP levels in observation group were lower than those in control group(P<0.05).The complication rate of observation group was significantly lower than that of control group(P<0.05).Conclusion:The clinical efficacy of hemoperfusion in the treatment of patients with acute organophosphorus poisoning can be significantly improved,which is conducive to the rehabilitation of patients,improve CHE activity,effectively inhibit inflammatory response,and alleviate the symptoms of patients with respiratory failure and liver injury.