马来酸依那普利叶酸片治疗H型高血压的效果及对脑卒中的预防作用

Effectiveness of Enalapril Maleate Folic Acid Tablets in the Treatment of H-type Hypertension and Prevention of Stroke

目的:分析马来酸依那普利叶酸片治疗H型高血压的效果及对脑卒中的预防作用。方法:选取2013年4月—2020年6月梧州市红十字会医院心内科治疗的H型高血压患者201例为研究对象,随机分为观察组(101例)和对照组(100例)。对照组口服厄贝沙坦片治疗,观察组口服马来酸依那普利叶酸片治疗。比较两组血压、血清同型半胱氨酸(Hcy)、不良反应发生情况、脑卒中发生率。结果:治疗前后,两组收缩压(SBP)、舒张压(DBP)水平比较,差异无统计学意义(P>0.05);治疗后,两组SBP、DBP水平低于治疗前,差异有统计学意义(P<0.05)。治疗前,两组Hcy水平比较,差异无统计学意义(P>0.05);治疗后,两组Hcy水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组脑卒中发生率低于对照组,差异有统计学意义(P=0.049)。结论:马来酸依那普利叶酸片治疗H型高血压患者可有效降低血压、Hcy水平及脑卒中发生率。

Objective:To analyze the effect of enalapril maleate folic acid tablets in the treatment of H-type hypertension and its preventive effect on stroke.Methods:Two hundred and ninety-one patients with H-type hypertension treated in the Department of Cardiology of Wuzhou Red Cross Hospital from April 2013 to June 2020 were selected for the study,and were randomly divided into the observation group(101 cases)and the control group(100 cases).The control group was treated with oral irbesartan tablets,and the observation group was treated with oral enalapril maleate folic acid tablets.The two groups were compared in terms of blood pressure,serum homocysteine(Hcy),occurrence of adverse reactions,and incidence of stroke.Results:Before and after treatment,the levels of systolic blood pressure(SBP)and diastolic blood pressure(DBP)of the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of SBP and DBP of the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).Before treatment,the levels of Hcy of the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the Hcy level of the two groups was lower than that before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Compared the incidence of adverse reactions in the two groups,the difference was not statistically significant(P>0.05);the incidence of stroke in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.049).Conclusion:Enalapril maleate folic acid tablets can effectively reduce blood pressure,Hcy level and stroke incidence in the treatment of H-type hypertension patients.