超重老年男性骨钙素与肌量的相关性研究

Correlation between serum osteocalcin and muscle mass in overweight elderly male

目的观察超重老年男性病人中,骨钙素与骨骼肌质量的相关性。方法收集2020—2022年南京鼓楼医院老年科收治的167例超重老年男性病人为研究对象,根据骨钙素水平分为低骨钙素组和正常骨钙素组,分析骨钙素与超重老年男性腰部肌量的相关性,并采用线性回归分析肌量的影响因素。结果2组间年龄、HbA1c、Ⅰ型胶原交联C末端肽(CTX)、Ⅰ型前胶原氨基端前肽(P1NP)、25-羟基维生素D、腰部肌量、髋部肌量差异均有统计学意义(P均<0.05)。骨钙素、CTX、P1NP均与髋部肌量及腰部肌量呈正相关(r=0.204~0.322,P均<0.05),年龄、BMI、腹围均与髋部肌量及腰部肌量呈负相关(r=-0.282~-0.187,P均<0.05)。多元线性回归分析显示,髋部肌量的独立影响因素为年龄、腹围(β=-0.081、-0.127,P均<0.05),腰部肌量的独立影响因素为年龄、腹围、骨钙素(β=-0.201、-0.136、0.187,P均<0.05)。结论超重老年男性病人腰部、髋部肌量与骨钙素呈正相关。骨钙素是腰部肌量的独立相关因素。

Objective To analyze the association between serum osteocalcin and muscle mass in overweight elderly male.Methods A total of 167 overweight elderly male patients admitted to Department of Geriatrics,Nanjing Drum Towel Hospital from January 2020 to December 2022 were enrolled in this study.The subjects were classified into low osteocalcin group and normal osteocalcin group based on the serum level of osteocalcin.The relationship between the serum level of osteocalcin and lumbar and hip muscle masses was analyzed.Multiple linear regression analysis was used to analyze the influencing factors of muscle mass.Results Significant differences were observed in age and the levels of glycosylated hemoglobin A1c(HbA1c),typeⅠcollagen cross-linked C-terminal peptide(CTX),typeⅠprocollagen amino terminal peptide(P1NP),25-hydroxy vitamin D,waist muscle mass and hip muscle mass between the two groups(all P<0.05).The lumbar muscle mass and hip muscle mass were positively correlated with the levels of osteocalcin,CTX and P1NP(r=0.204-0.322,all P<0.05),and negatively correlated with age,BMI and abdominal circumference(r=-0.282--0.187,all P<0.05).Multiple linear regression analysis showed that age and abdominal circumference were the independent influencing factors of hip muscle mass(β=-0.081 and-0.127,both P<0.05),while age,abdominal circumference and osteocalcin were the independent influencing factors of lumbar muscle mass(β=-0.201,-0.136,0.187,all P<0.05).Conclusions There are positive correlations between lumbar and hip muscle masses and serum level of osteocalcin in overweight elderly male patients.Furthermore,osteocalcin is an independent influencing factor of lumbar muscle mass.