摘要
The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and proteostasis.In this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements.We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases.In summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.
基金
supported by the National Natural Science Foundation of China,Nos.92049120 and 81870897
STI2030-Major Projects,No.2021ZD0204001
Guangdong Key Project for Development of New Tools for the Diagnosis and Treatment of Autism,No.2018B030335001
the Natural Science Foundation of Jiangsu Province,No.BK20181436
the National Major Scientific and Technological Special Project for Significant New Drug Development,No.2019ZX09301102
the Discipline Construction Program of the Second Affiliated Hospital of Soochow University,No.XKTJ-TD202003
Sino-German Cooperation Mobility Programme,No.M-0679
the Science and Technology Project of Suzhou,No.SKY2022161
Research Project of Neurological Diseases of the Second Affiliated Hospital of Soochow University Medical Center,No.ND2023A01(all to QHM)。
