摘要
Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after IS.Acupuncture can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and fatigue.However,the mechanisms underlying the effects of acupuncture in IS remain unclear.Available evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and immunity.Further studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.
基金
funded by the Ministry of Science and Technology of the People’s Republic of China,National Key Research and Development Program(2018YFC1706001)
Tianjin Municipal Science and Technology Bureau,Tianjin Science and Technology Plan Project(21JCQNJC01560)
Tianjin Education Commission scientific research project(2022KJ170)
Tianjin Municipal Education commission
Tianjin Graduate Research Innovation Project(Service Industry Project)(2022BKYZ046)
Tianjin University of Traditional Chinese Medicine
Tianjin University of Traditional Chinese Medicine Graduate Research Innovation Project(Clinical Research Project YJSKC-20222002)
the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Exploration and Innovation Project(YB202112).
