椎间孔及浅筋膜内注射三氧活化的自体血浆治疗带状疱疹后神经痛

Treatment of postherpetic neuralgia by injecting autologous plasma activated with ozone into the intervertebral foramen and superficial fascia

目的:探讨椎间孔及浅筋膜内注射三氧活化的自体血浆治疗带状疱疹后神经痛(postherpetic neuralgia,PHN)的疗效和安全性。方法:选取2023年5月4日至2023年7月14日北京中医药大学东方医院疼痛科就诊的PHN病人30例,所有病人均接受受损侧对应椎间孔及浅筋膜内注射三氧活化的自体血浆治疗。记录所有病人的治疗效果和不良反应,同时比较治疗前及治疗后1周、2周、1个月的疼痛数字分级评分法(numerical rating scale,NRS)评分、焦虑自评量表(self-rating anxiety scale,SAS)评分、抑郁自评量表(self-rating depression scale,SDS)评分、匹兹堡睡眠质量指数(Pittsburg sleep quality index,PSQI)及生活质量评分(quality of Life,QOL)。结果:30例病人的治疗总有效率为93.3%,未发生明显不良反应和不良事件。治疗后1周、2周及1个月,所有病人的NRS、SAS、SDS及PSQI总体评分均明显低于治疗前(P<0.001);QOL总体评分明显高于治疗前(P<0.001);组内各时间点比较总体差异有统计学意义(P<0.001)。结论:椎间孔及浅筋膜内注射三氧活化的自体血浆治疗PHN疗效显著,且无明显不良反应和不良事件,可以明显缓解PHN病人疼痛程度,有效改善其情绪状态、提升病人的睡眠及生活质量,安全性较高。

Objective:We aim to investigate the effectiveness and safety of injection of autologous plasma activated with ozone into the intervertebral foramen and superficial fascia for the treatment of postherpetic neuralgia(PHN).Methods:From May 4,2023 to July 14,2023,a total of 30 patients with PHN were selected from the Pain Department of Dongfang Hospital Beijing University of Chinese Medicine.All patients received treatment with the injection of autologous plasma activated with ozone into their respective intervertebral foramen and superficial fascia on the injuried side.The treatment efficacy and adverse reactions of all patients will be recorded,and the Numerical rating scale(NRS),Self-rating anxiety scale(SAS),Self-rating depression scale(SDS),Pittsburg sleep quality index(PSQI),and quality of life(QOL)scores will be compared before and 1 week,2 weeks,and 1 month after treatment.Results:The overall effective rate of treatment for all patients amounts to 93.3%,with no significant adverse reactions or events occurring.Following treatment for 1 week,2 weeks,and 1 month,the overall scores of NRS,SAS,SDS,and PSQI for all patients were significantly reduced compared to those before treatment,with statistically significant differences(P<0.001).The overall score of QOL was significantly higher than before treatment,indicating statistically significant differences(P<0.001).The overall difference among different time points is statistically significant(P<0.001).Conclusion:The treatment of postherpetic neuralgia through injection of autologous plasma activated with ozone into the intervertebral foramen and superficial fascia is not only highly effective but also no significant adverse reactions or events.It can greatly reduce the pain level of patients suffering from postherpetic neuralgia,thereby enhancing their emotional state,sleep,and quality of life,while also boasting high safety.