母婴分离对子代行为及大脑影响的研究进展

Research progress on the impact of mother-infant separation on offspring behavior and brain

个体在生命早期遭遇不幸事件(虐待、忽视等),即生命早期应激(ELS),会导致其成年后的大脑结构和功能发生改变,增加各类精神疾病(如抑郁症、创伤后应激障碍及精神分裂症等)的患病风险。为模拟人类幼年时期留守现象,啮齿动物的母婴分离(MS)模型得到广泛应用,有助于揭示ELS诱发疾病发生发展的机制。文章通过对大、小鼠MS模型的行为学及相关脑区改变的研究成果进行综述。

Early life stress(ELS),those unfortunate events(abuse,neglect,etc.)encountered by individuals,will lead to changes in brain structure and function in adulthood,and increase the risk of mental diseases,such as depression,post-traumatic stress disorder and schizophrenia.In order to simulate the phenomenon of human left-behind children,the mother-infantseparation(MS)model of rodents have been widely used,which is helpful to reveal the mechanism of the occurrence and development of ELS-induced diseases.This article systematically reviewed the research results of behavior and changes in the related brain regionsin MS models of rodents.