甘草泻心汤对急性有机磷中毒邪结胃肠型患者的影响

Effects of Gancao Xiexin Decoction on patients with acute organophosphorus poisoning and a syndrome of pathogens bound in stomach and intestine

目的观察甘草泻心汤对急性有机磷中毒邪结胃肠型患者的影响。方法选择亳州市中医院治疗的急性有机磷中毒邪结胃肠型患者80例,按随机数表法分为对照组与观察组,各40例。对照组给予常规西医对症治疗,观察组在对照组治疗基础上给予甘草泻心汤治疗,治疗前后检测2组肿瘤坏死因子-α(TNF-α)、二胺氧化酶(DAO)、白细胞介素1β(IL-1β)、肌钙蛋白(cTnI)、D-乳酸(D-LA)、瓜氨酸、肌红蛋白(MYO)、氧磷酯酶1(PON1)、丙二醛(MDA)、超氧化物歧化酶(SOD)、总胆红素(TBil)、丙氨酸氨基转移酶(ALT)水平,比较2组治疗前后中医证候评分,记录苏醒时间、胆碱酯酶恢复正常时间,比较2组临床疗效及并发症。结果治疗后,观察组IL-1β、TNF-α、MDA、cTnI、MYO、TBil、ALTA、DAO、D-LA含量、中医证候评分低于对照组(P<0.05),SOD、PON1、瓜氨酸含量高于对照组(P<0.05);苏醒时间、胆碱酯酶恢复正常时间短于对照组(P<0.05);观察组总有效率(97.50%,39/40)高于对照组(87.50%,35/40)(P<0.05);观察组并发症总发生率低于对照组(P<0.05)。结论甘草泻心汤治疗急性有机磷中毒邪结胃肠型患者,可抑制炎症,减少氧化应激、肝功能及心肌损伤,保护胃肠黏膜,提升疗效,减少并发症。

Objective To observe the effects of Gancao Xiexin Decoction on patients with acute organophosphorus poisoning with the pathogens bound in stomach-intestine pattern.Methods Eighty patients with acute organophosphorus poisoning with the pathogens bound in stomach-intestine pattern,treated at Bozhou Traditional Chinese Medicine Hospital,were selected as subjects for the study and divided into a control group and an observation group by the random number table method,with 40 cases in each group.The control group was given a conventional western medicine symptomatic treatment,while the observation group received a treatment with Gancao Xiexin Decoction on the basis of the control group.The levels of tumor necrosis factor-α(TNF-α),diamine oxidase(DAO)and interleukin 1β(IL-1β),troponin(cTnI),D-lactate(D-LA),citrulline,myoglobin(MYO),oxophosphatase 1(PON1),malondialdehyde(MDA),superoxide dismutase(SOD),total bilirubin(TBil)and alanine aminotransferase(ALT)were evaluated in the two groups before and after treatment.The TCM syndrome scores were compared between the two groups before and after treatment,and the patients'recovery time and cholinesterase recovery time were recorded.The clinical efficacy and incidence of complications were compared between the two groups.Results After treatment,the contents of IL-1β,TNF-α,MD,cTnI,MYO,TBil,ALTA,DAO,D-LA,the TCM syndrome scores were lower in the observation group than those in the control group(P<0.05),while the contents of SOD,PON1,citrulline were higher than those in the control group(P<0.05).After treatment,the recovery time and the cholinesterase recovery time were shorter than those in the control group(P<0.05).After treatment,the total effective rate of the observation group(97.50%,39/40)was higher than that of the control group(87.50%,35/40)(P<0.05).After treatment,the total incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion In the treatment of patients with acute organophosphorus poisoning and a syndrome of pathogens bound in the stomach and intestine,Gancao Xiexin Decoction can inhibit inflammation,reduce oxidative stress,liver function injury and myocardial damage,protect gastrointestinal mucosa,improve curative effect and reduce complications.