黄精化学成分、药理作用研究进展及质量标志物(Q-Marker)预测分析

Research progress on chemical components and pharmacological effects ofPolygonati Rhizoma and prediction analysis of quality marker

中药黄精为百合科、黄精属植物黄精Polygonatum sibiricum Red.、多花黄精Polygonatum cyrtonema Hua或滇黄精Polygonatum kingianum Coll.et Hemsl.的干燥根茎,用药历史悠久,性平、味甘,归脾、肺、肾经,具有养阴润肺、补脾益气、滋肾填精之功效,用于治疗肺虚燥咳、脾胃虚弱、体倦乏力、口干食少、精血不足、内热消渴等。本文对黄精的化学成分及现代药理研究进行综述,并基于其药理活性、药效物质、植物亲缘学、药材配伍、加工炮制和网络药理学等研究,预测分析了其质量标志物(quality markers,Q-marker)。初步确定黄芩素、甘草素、β-谷甾醇、薯蓣皂苷元、5,4′-二羟基黄酮、3′-甲氧基大豆苷、新甘草苷和黄精多糖为黄精的质量标志物,为黄精质量控制和临床用药提供参考依据。

Polygonati Rhizoma is the rhizomes of Polygonatum sibiricum Red.,P.cyrtonema Hua or P.kingianum Coll.et Hemsl.in the plants of the Polygonatum Mill.in the Liliaceae family,with a long history of medicinal use,flat nature,sweet taste,spleen,lung,and kidney meridian.It is used for the treatment of lung deficiency and dry cough,weakness of the spleen and stomach,tiredness and fatigue,dry mouth and little food,deficiency of essence and blood,internal heat and thirst.In this paper,we reviewed the chemical components and modern pharmaceuticals,studied rhizoma polygonal odor,predicted and analyzed its quality markers(Q-markers)based on pharmacological activities,pharmacodynamic substances,phytopharmacology,herb compounding,processing and concocting,and network pharmacology.Preliminarily,baicalein,glycyrrhizin,β-sitorsterol,diosgenin,5,4′-dihydroxyflavone,3′-methoxy-solo side,neo glycyrrhizin,and polysaccharides of flavonoids were identified as quality markers,which will provide a reference basis for the quality control and the clinical use of the drug.