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A型肉毒毒素防治额部外伤瘢痕的美学效果及对血清TGF-β_(1)、BMP-7水平的影响

Aesthetic Effect of Botulinum Toxin Type A on the Prevention and Treatment of Frontal Trauma Scar and the Infl uence of Serum TGF-β_(1) and BMP-7 levels
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摘要 目的:探讨A型肉毒毒素防治额部外伤瘢痕的美学效果及对血清TGF-β_(1)、BMP-7水平的影响。方法:选取2020年7月-2022年10月笔者医院收治的84例额部外伤患者为研究对象,按随机数字表法分为观察组和对照组,各42例。对照组采用清创美容缝合联合外用硅凝胶制剂防治瘢痕;观察组采用美容缝合拆线后伤口两侧注射A型肉毒毒素防治瘢痕。拆线后3个月,统计比较两组瘢痕临床防治有效率、瘢痕评分[温哥华瘢痕量表(Vancouver scar scale,VSS)]、瘢痕疼痛或瘙痒程度评分[视觉模拟评分法(Visual analogue scale,VAS)]、患者满意度、血清转化生长因子β_(1)(Transforming growth factor-β_(1),TGF-β_(1))和骨成型蛋白7(Recombinant bone morphogenetic protein 7,BMP-7)水平及不良反应。结果:观察组VSS评分、瘢痕疼痛或瘙痒程度VAS评分低于对照组(P<0.05);观察组瘢痕临床防治有效率为90.47%,高于对照组的69.04%(P<0.05);观察组患者满意度高于对照组(P<0.05);观察组TGF-β_(1)水平低于对照组,BMP-7水平高于对照组(P<0.05);两组均未发生严重不良反应。结论:额部软组织外伤患者美容缝合拆线后伤口两侧注射A型肉毒毒素可抑制瘢痕形成,有效提升瘢痕防治有效率及患者满意度,其临床效果可能与调控血清TGF-β_(1)和BMP-7水平有关,且安全性较高,具有一定的临床应用价值。 Objective To investigate the aesthetic effect of botulinum toxin type A in the prevention and treatment of frontal trauma scar and its influence on serum TGF-β_(1) and BMP-7 levels.Methods A total of 84 patients with frontal trauma admitted to the author's hospital from July 2020 to October 2022 were selected as the research objects.According to the random number table method,they were divided into the observation group and the control group,with 42 cases in each group.The control group was treated with debridement and cosmetic suture combined with topical silicone gel preparation to prevent and treat scar.In the observation group,botulinum toxin type A was injected on both sides of the wound after the cosmetic suture was removed to prevent scar.Three months after the stitches were removed,the effective rate of clinical prevention and treatment of scar,scar score[Vancouver scar scale(VSS)],scar pain or pruritus score[visual analogue scale,VAS],patient satisfaction,serum transforming growth factor-β_(1)(TGF-β_(1))level,recombinant bone morphogenetic protein 7(BMP-7)level and adverse reactions were compared between the two groups.Results The VSS score and VAS score of scar pain or pruritus in the observation group were lower than those in the control group(P<0.05).The effective rate of clinical prevention and treatment of scar in the observation group was 90.47%,which was higher than 69.04%in the control group(P<0.05).The satisfaction of patients in the observation group was higher than that in the control group(P<0.05).The level of TGF-β_(1) in the observation group was lower than that in the control group,and the level of BMP-7 was higher than that in the control group(P<0.05).No serious adverse reactions occurred in the two groups.Conclusion Injection of botulinum toxin type A on both sides of the wound in patients with frontal soft tissue trauma after cosmetic suture removal can inhibit scar formation,effectively improve the efficiency of scar prevention and treatment and patient satisfaction.Its clinical effect may be related to the regulation of serum TGF-β_(1) and BMP-7 levels,and it is safe and has certain clinical application value.
作者 彭梦龙 桂艳鸾 王荣 PENG Menglong;GUI Yanluan;WANG Rong(Department of Burns and Plastic Surgery,Huanggang Central Hospital,Huanggang 438000,Hubei,China;Department of Dermatology,Huanggang Central Hospital,Huanggang 438000,Hubei,China)
出处 《中国美容医学》 CAS 2024年第6期30-33,共4页 Chinese Journal of Aesthetic Medicine
关键词 A型肉毒毒素 额部外伤 瘢痕 转化生长因子β_1 骨成型蛋白7 botulinum toxin type A forehead trauma scar transforming growth factor-β1 recombinant bone morphogenetic protein 7
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