Toll样受体4信号通路在心力衰竭中的应用价值

Application Value of Toll-Like Receptor 4 Signaling Pathway in Heart Failure

心力衰竭是全球发病率最高的疾病之一,在心力衰竭及其合并症的发生和发展过程中炎症机制起着至关重要的作用。大量研究表明Toll样受体4信号通路可通过介导不同的炎症因子,对心肌造成损害。因此近期发现Toll样受体4信号通路可用于预测心力衰竭及其合并症病情的严重程度及预后,同时也可作为许多新型抗心力衰竭药物的靶点,改善症状,使心力衰竭患者获益。现就Toll样受体4信号通路在心力衰竭中上述两方面的应用价值做一综述。

Heart failure is one of the most prevalent diseases in the world,and inflammation plays a crucial role in the occurrence and development of heart failure and its comorbidities.A large number of studies have shown that the Toll-like receptor 4 signaling pathway can cause damage to the myocardium by mediating different inflammatory factors.Therefore,it has recently been found that the Toll-like receptor 4 signaling pathway can be used to predict the severity and prognosis of heart failure and its comorbidities,and at the same time,it can also be used as a target for many new anti-heart failure drugs to improve symptoms and benefit patients with heart failure.This article reviews the application value of the Toll-like receptor 4 signaling pathway in the above two aspects in heart failure.