转化生长因子-β_(1)诱导多脏器纤维化机制的研究进展

Research progress on the mechanism of multiple organ fibrosis induced by transforming growth factorβ_(1)

脏器纤维化是多种慢性疾病的共同病理标志,转化生长因子-β_(1)(TGF-β_(1))可促进肌成纤维细胞增殖与活化,促进细胞外基质沉积并抑制其降解,并通过介导经典通路参与纤维化的发生。文章结合炎性反应和免疫应答、非编码RNA(ncRNA)以及信号通路之间串扰的相互作用,对TGF-β_(1)诱导各脏器纤维化的具体分子机制进行综述。

Organ fibrosis is a common pathological marker of a variety of chronic diseases.In this paper,under the background of the study of transforming growth factor-β_(1)(TGF-β_(1))mediated classical pathway,the specific molecular mechanism of TGF-β_(1) induced fibrosis of various organs was summarized in combination with the interaction between inflammation and immune response,non-coding RNA(ncRNA)and signaling pathways.