纤支镜下刷检薄层液基细胞学检查在肺癌诊断价值的研究

Study on the Value of Liquid-based Cytology Test in the Diagnosis of Lung Cancer

目的:研究纤支镜下刷检薄层液基细胞学检查(LCT)在肺癌诊断价值。方法:选取2023年4月到2024年3月间江门市新会区人民医院呼吸与危重症医学科首诊患者80名,所有患者均采用传统支气管镜活检、刷检涂片细胞学检查和刷检LCT检查的方法。传统刷检涂片细胞学检查(CS)为对照组,支气管镜刷检LCT检查为液基组,支气管镜活检为钳检组。对比各组对肺癌诊断阳性率,分析液基组及对照组对肺癌组织类型的检查情况,对比两组对肺癌组织类型的检查结果。结果:液基组对肺癌诊断的阳性率为40.00%(32/80),较对照组的25.00%(20/80)明显更高(P<0.05)。但液基组与钳检组比较,差异不显著(P>0.05)。LCT对肺癌鳞癌诊断的符合率为83.33%(10/12),对腺癌的诊断符合率为42.86%(6/14),对小细胞癌的诊断符合率为75.00%(9/12)。CS对肺癌鳞癌诊断的符合率为41.67%(5/12),对腺癌的诊断符合率为66.67%(8/12),对小细胞癌的诊断符合率为35.71%(5/14)。液基组对于肺癌组织类型为鳞癌以及小细胞癌的符合率较对照组更高(P<0.05),但两组对腺癌的符合率比较,差异不显著(P>0.05)。结论:应用纤支镜下刷检LCT检查在肺癌的诊断价值较高,且值得在临床诊断过程中给予推广。

Objective:To study the value of Liquid-based cytology test in the diagnosis of lung cancer.Methods:80 patients were first diagnosed in Department of Respiratory and Critical Care Medicine of People’s Hospital of Xinhui district of Jiangmen city from April 2023 to March 2024,and all the patients adopted the methods of traditional bronchoscopy biopsy,brush smear cytology and brush Liquid-based cytology test.Cytology of traditional brush coventional smear(CS)was the control group,bronchoscopy Liquid-based cytology test(LCT)was the fluid base group,and bronchoscopy biopsy was the forceps group.The positive rate of lung cancer diagnosis of each group,the examination of the liquid base group and the control group,and the two groups were compared Examination results of lung cancer tissue types.Results:The positive rate of lung cancer diagnosis in the liquid base group was 40.00%(32/80),which was significantly higher than 25.00%(20/80)in the control group(P<0.05).However,the difference between the liquid base group and the forceps group was not significant(P>0.05).The coincidence rate of LCT was 83.33%(10/12),42.86%(6/14),and 75.00%(9/12).The coincidence rate of CS for the diagnosis of squamous cell carcinoma of lung cancer was 41.67%(5/12),the diagnostic concordance rate for adenocarcinoma was 66.67%(8/12)and 35.71%(5/14).The coincidence rate for squamous carcinoma and small cell carcinoma was higher in the control group(P<0.05),but the difference for adenocarcinoma was not significant(P>0.05).Conclusion:The diagnosis of lung cancer and should be used in clinical diagnosis.