甘草抗炎活性物质基础及其作用机制研究进展

Research Progress on Anti-Inflammatory Active Substances and Their Mechanism of Action in Gancao(Glycyrrhizae Radix Et Rhizoma)

炎症是机体对于刺激所产生的一种防御反应,随着炎症的发展可能导致组织的变异和增生,进一步加剧疾病的进程。甘草作为“众药之王”“国之药老”,早在《神农本草经》中就记载其清热作用较强,能“主五脏六腑寒热邪气”。现代研究表明,甘草提取物对肾小球肾炎、结肠炎症状改善明显,甘草及其制剂在治疗肝炎、胃炎、支气管炎、心肌炎、强直性脊柱炎等炎症性疾病方面亦具有一定的独特优势和发展潜力。该文旨在通过对近期国内外甘草抗炎活性物质基础及其作用机制方面的相关文献进行收集和整理,探索甘草发挥抗炎作用的主要活性成分及靶点通路,以期为甘草抗炎作用的进一步研究及抗炎药物的研发提供思路和参考。

Inflammation is a defensive response produced by the body to stimulation.With the development of inflammation,it may lead to the variation and proliferation of tissues,further aggravating the process of disease.Gancao(Glyeyrthizae Radix Et Rhizoma)is the"king of all drugs"and"Guolao of the drugs".As early as in Shennong Bencao Classic,it recorded the strong heat-clearing effect of Gancao(Glyeyrhizae Radix Et Rhizoma)and it can treat"the cold and heat evils of five Zang organs and six Fu organs".Modern studies have shown that Gancao(Glycyrhizae Radix Et Rhizoma)extract can significantly improve the symptoms of glomerulonephritis and colitis,and Gancao(Glycyrhizae Radix Et Rhizoma)and its preparations have certain unique advantages and development potential in the treatment of hepatitis,gastritis,bronchitis,myocarditis,ankylosing spondylitis and other inflammatory diseases.The purpose of this study was to explore the main active ingredients and target pathway of the anti-inflammatory effects of Gancao(Glycyrrhizae Radix Et Rhizoma)through the collection and collation of recent domestic and for-eign literatures on the basis of the anti-inflammatory substances and their mechanism of action,in order to provide ideas and ref-erences for the further research on the anti-inflammatory effects of Gancao(Glycyrrhizae Radix Et Rhizoma)and the research and development of anti-inflammatory drugs.