血清残余胆固醇、甘油三酯-葡萄糖指数与青年H型高血压的关系

Relationship Between Serum Residual Cholesterol, Triglyceride-Glucose Index and H-type Hypertension

目的 探讨血清残余胆固醇(RC)和甘油三酯-葡萄糖指数(TyG)与青年H型高血压患者的关系。方法 收集阜外华中心血管病医院在2020年1月至2023年4月期间,住院诊治的青年高血压患者290例作为实验组,根据血清同型半胱氨酸(Hcy)水平,将实验组又分为H型高血压组170例,正常Hcy高血压组(单纯高血压组)120例;另选取同期健康体检者90例作为正常对照组。选用Cobas8000全自动生化分析仪检测3组血标本中Hcy、血脂、肾功能等生化指标,采用单因素方差分析比较3组之间水平的差异。采用Pearson相关法分析Hcy与总胆固醇(TC)、RC、TyG、尿素氮(BUN)、肌酐(Cr)、尿酸(UA)的相关性。采用多因素logistic回归分析H型高血压患者的影响因素。结果 H型高血压组和单纯高血压组中BUN、Cr、UA、GFR水平均高于正常对照组,且H型高血压组较单纯高血压组有升高趋势,差异有统计学意义(P<0.05)。H型高血压组和单纯高血压组中CHO、RC、TyG水平均高于正常对照组,且H型高血压组较单纯高血压组有升高趋势,差异有统计学意义(P<0.05)。多因素logistic回归分析发现,性别、RC、TyG、BUN、Cr、UA是H型高血压患者高Hcy的影响因素。结论 H型高血压患者高Hcy与TyG、RC相关,临床可根据患者TyG、RC水平采取治疗措施,预防H型高血压的发生。

Objective To explore the relationship between serum residual cholesterol(RC),triglyceride glucose(TyG)index and young patients with H-type hypertension.Methods A total of 290 young hypertensive patients admitted to the Huazhong Cardiovascular Hospital in Fuwai from January 2020 to April 2023 were collected as the experimental group.Based on serum homocysteine(Hcy)levels,the experimental group was further divided into an H-type hypertension group of 170 cases and a normal Hcy hypertension group(pure hypertension group)of 120 cases.Another 90 healthy individuals who underwent physical examinations during the same period were selected as the normal control group.The Cobas8000 fully automatic biochemical analyzer was used to detect biochemical indicators such as Hcy,blood lipids,and renal function in three groups of blood samples.Single factor analysis of variance was used to compare the differences in levels among the three groups.Pearson correlation method was used to analyze the correlation between Hcy and total cholesterol(TC),RC,TyG,blood urea nitrogen(BUN),creatinine(Cr),and uric acid(UA).Multiple logistic regression analysis was used to identify the influencing factors of H-type hypertension patients.Results The levels of BUN,Cr,UA,and GFR in the H-type hypertension group and the simple hypertension group were higher than those in the normal control group,and the H-type hypertension group showed an upward trend compared to the simple hypertension group,with statistical significance(P<0.05).The levels of CHO,RC,and TyG in the H-type hypertension group and the simple hypertension group were higher than those in the normal control group,and the H-type hypertension group showed an upward trend compared to the simple hypertension group,with statistical significance(P<0.05).Multivariate logistic regression analysis found that gender,RC,TyG,BUN,Cr,UA were the influencing factors for high Hcy in patients with H-type hypertension.Conclusion High Hcy in patients with H-type hypertension is associated with TyG and RC levels.Clinical treatment measures can be taken based on the patient’s TyG and RC levels to prevent the occurrence of H-type hypertension.