特发性矮小症发生影响因素及血清鸢尾素、性激素结合球蛋白的临床诊断价值

Influencing Factors of Idiopathic Dwarfism and the Clinical Diagnostic Value of Serum Irisin and Sex Hormone Binding Globulin

目的 探究特发性矮小症发生影响因素以及血清鸢尾素、性激素结合球蛋白在该类患儿中的表达水平和临床诊断价值。方法 收集南阳市中心医院2020年5月至2022年10月诊治的86例特发性矮小症患儿为疾病组,另外收集86例在同一时期进行体检的健康儿童作为对照组。采用酶联免疫吸附法(ELISA)检测两组儿童血清中鸢尾素、性激素结合球蛋白表达水平,logistic回归分析特发性矮小症发生的影响因素;受试者工作特征(ROC)曲线评估鸢尾素、性激素结合球蛋白表达水平对特发性矮小症患儿的诊断价值。结果 疾病组血清鸢尾素、性激素结合球蛋白水平均低于对照组(P<0.05);多因素logistic回归分析结果显示,血清鸢尾素、性激素结合球蛋白、性发育状态、骨龄指数是发生特发性矮小症的影响因素(P<0.05);血清鸢尾素、性激素结合球蛋白两者分别诊断特发性矮小症患儿的曲线下面积(AUC)为0.816、0.871,两者联合诊断特发性矮小症患儿的AUC为0.941,两者联合优于血清鸢尾素、性激素结合球蛋白各自单一诊断(Z=3.896、3.500,P<0.05)。结论 特发性矮小症患儿血清中鸢尾素、性激素结合球蛋白表达水平均较低,且两者均是儿童发生特发性矮小症的影响因素,两者联合监测对特发性矮小症早期诊断有一定的应用价值。

Objective To explore the influencing factors of idiopathic short stature and the expression levels and clinical diagnostic value of serum irisin and sex hormone binding globulin in children with this condition.Methods A total of 86 children with idiopathic short stature who underwent diagnosis and treatment in Nanyang Central Hospital from May 2020 to October 2022 were regarded as the disease group,in addition,86 healthy children who underwent physical examinations were collected as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to detect the expression levels of irisin and sex hormone binding globulin in the serum of children in two groups.Logistic regression was used to analyze the influencing factors of idiopathic nanosomia,and receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of irisin and sex hormone binding globulin expression levels in children with idiopathic short stature.Results The serum levels of irisin and sex hormone binding globulin in the disease group were lower than those in the control group(P<0.05).The results of multivariate logistic regression analysis showed that serum irisin,sex hormone binding globulin,sexual development status,and bone age index were the influencing factors for the occurrence of idiopathic short stature(P<0.05).The area under the curve(AUC)of serum irisin and sex hormone binding globulin in diagnosing children with idiopathic short stature were 0.816 and 0.871,respectively.The AUC of the combination of the two in diagnosing children with idiopathic short stature was 0.941,which was better than the single diagnosis of serum irisin and sex hormone binding globulin(Z=3.896,3.500,P<0.05).Conclusion The expression levels of irisin and sex hormone binding globulin in the serum of children with idiopathic short stature are low,and both are influencing factors for the development of idiopathic short stature in children.The combined monitoring of the two has certain application value for early diagnosis of idiopathic short stature.