参麦注射液辅助化疗治疗中晚期消化道肿瘤的效果及对免疫因子的影响

Effect of Ginseng-mai Injection Adjuvant Chemotherapy in Treating middle and Advanced Digestive Tract Tumours and its Effect on Immune Factors

目的探讨参麦注射液辅助化疗治疗中晚期消化道肿瘤的效果及对免疫因子的影响。方法选择扬中市中医院2022年1月-2023年6月收治的中晚期消化道肿瘤患者86例,以随机数字表法分组,对照组(n=43)使用化疗治疗,观察组(n=43)在此基础上辅助以参麦注射液治疗。对比两组临床治疗效果、肿瘤标记物水平、免疫指标与不良反应发生情况。结果观察组疾病控制率、客观缓解率均高于对照组,差异有统计学意义(P<0.05);治疗后,两组CEA、CA125、CA199水平均下降,且观察组肿瘤标记物水平较对照组更低,差异有统计学意义(P<0.05)。治疗后,两组CD3+、CD4+、CD4+/CD8+均升高,CD8+均下降,且观察组各项指标均优于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论对中晚期消化道肿瘤患者采用参麦注射液辅助化疗治疗的效果确切,可降低肿瘤标记物水平,调节免疫因子,且不良反应少,值得临床推广。

Objective:To investigate the effect of Shenmai injection in adjuvant chemotherapy for advanced digestive tract tumors and its influence on immune factors.Methods:Eighty-six patients with advanced digestive tract tumor admitted to Yangzhong Hospital of Traditional Chinese Medicine from January 2022 to June 2023 were randomly divided into two groups.The control group(n=43)was treated with chemotherapy,and the observation group(n=43)was treated with Shenmai injection.The clinical therapeutic effect,tumor marker level,immune index and adverse reactions were compared between the two groups.Results:The disease control rate and objective remission rate in the observation group were higher than those in the control group,with statistical significance(P<0.05).After treatment,the levels of CEA、CA125 and CA199 in both groups decreased,and the level of tumor markers in the observation group was lower than that in the control group,with statistical significance(P<0.05).After treatment,CD3+、CD4+、CD4+/CD8+in both groups increased,while CD8+decreased,and all indexes in the observation group were better than those in the control group,with statistical significance(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Shenmai injection is effective in adjuvant chemotherapy for patients with advanced digestive tract tumors,which can reduce the level of tumor markers and regulate immune factors,and has few adverse reactions,which is worthy of clinical promotion.