“长新冠”的机制研究进展

Progress on the mechanism of long COVID

“长新冠”是一种新冠病毒感染后持续存在多系统症状的病理生理状态,其发病机制与病毒持续存在引起的免疫及炎症反应失调、微生态失调、迷走神经功能异常和代谢改变等多种因素有关。目前“长新冠”的治疗策略主要建立在对症支持治疗的基础上,尚无标准的治疗方案,未来可能的治疗方向包括阻止病毒入侵、调节免疫反应、调节微生态及改善神经和代谢功能等。“长新冠”病理生理机制需要进一步的深入研究,以指导管理和治疗“长新冠”患者。

Long COVID is a pathological condition characterized by persistent multi-system symptoms post SARS-CoV-2 infection.Factors contributing to its development include ongoing viral presence,dysregulated immune and inflammatory responses,changes in microbiota,vagus nerve dysfunction,and metabolic alterations.Treatment currently centers around symptom management due to the lack of a standardized approach.Potential future directions for treatment involve preventing viral invasion,modulating immune responses,regulating microbiota,and enhancing neurological and metabolic function.Additional research is needed to comprehend the mechanisms underlying long COVID and guide the management and treatment of those affected.