拉氧头孢钠联合前列地尔治疗急性附睾炎的临床效果及安全性

Clinical Efficacy and Safety of Latamoxef Sodium Combined with Alprostadil in the Treatment of Acute Epididymitis

目的:探讨拉氧头孢钠联合前列地尔治疗急性附睾炎的临床效果及安全性。方法:选择2021年8月—2023年9月在三峡大学附属第一临床医学院治疗的急性附睾炎患者90例,参照随机数字表法进行划分,其中45例纳入常规治疗组(拉氧头孢钠),45例纳入联合治疗组(前列地尔+拉氧头孢钠)。统计两组患者的Barthel指数评分、附睾体积、退热时间、尿路感染(UTI)缓解时间、治疗总有效率及不良反应发生率。结果:治疗前,两组患者的Barthel指数评分、附睾体积比较,差异均无统计学意义(P>0.05);联合治疗组患者治疗后的Barthel指数评分明显高于常规治疗组,附睾体积明显小于常规治疗组(P<0.05)。与常规治疗组比较,联合治疗组患者的退热时间、UTI缓解时间均明显更早,治疗总有效率更高,用药后的不良反应发生率更低(P<0.05)。结论:采取拉氧头孢钠联合前列地尔对急性附睾炎患者进行治疗,能够有效提高其治疗总有效率,改善患者生活质量,不良反应发生率较低。

Objective:To investigate the clinical effect and safety of Latamoxef Sodium combined with Alprostadil in the treatment of acute epididymitis.Method:A total of 90 patients with acute epididymitis treated in the First Clinical Medical College Affiliated to China Three Gorges University from August 2021 to September 2023 were selected and divided according to the random number table method,of which 45 were included in the conventional treatment group(Latamoxef Sodium)and 45 were included in the combined treatment group(Alprostadil+Latamoxef Sodium).The Barthel index score,epididymis volume,fever remission time,urinary tract infection(UTI)remission time,total effective rate and incidence of adverse reactions were analyzed in the two groups.Result:Before treatment,there were no significant differences in Barthel index score and epididymal volume between the two groups(P>0.05);the Barthel index score of the combined treatment group was significantly higher than that of the conventional treatment group,and the epididymal volume was significantly lower than that of the conventional treatment group(P<0.05).Compared with the conventional treatment group,the time of fever reduction and UTI remission in the combined treatment group were significantly earlier,the total effective rate of treatment was higher,and the incidence of adverse reactions after medication was lower(P<0.05).Conclusion:In the treatment of patients with acute epididymitis,the total effective rate and quality of life of patients can be effectively improved by the combination of Latamoxef Sodium and Alprostadil,and the incidence of adverse reactions is low.