基于DTI-ALPS评估中枢神经系统疾病患者类淋巴系统功能的研究进展

Research progress on the glymphatic system of patients with central nervous system diseases based on diffusion tensor image analysis along the perivascular space

类淋巴系统(glymphatic system,GS)是近年出现的探究中枢神经系统疾病生理病理机制的新兴角度。研究证实沿血管周围间隙扩散张量分析(diffusion tensor image analysis along the perivascular space,DTI-ALPS)能够有效地评估中枢神经系统疾病患者GS功能改变,尤其是在退行性中枢神经系统疾病,如癫痫、帕金森病、痴呆。本文就应用DTI-ALPS技术评估中枢神经系统疾病患者GS功能的研究现状作一综述,旨在为疾病的神经影像研究提供新方向。

The glymphatic system(GS)is an emerging perspective in exploring the physiological and pathological mechanisms of central nervous system diseases in recent years.Research has confirmed that the diffusion tensor image analysis along the perivascular space(DTI-ALPS)method can effectively evaluate the functional changes of the GS in patients with central nervous system diseases,especially in degenerative central nervous system diseases,such as epilepsy,Parkinson's disease,and dementia.This article reviews the current research status of applying DTI-ALPS technology to evaluate GS function in patients with central nervous system diseases,aiming to provide new directions for neuroimaging research.