不同根管冲洗液对慢性牙髓炎患者根管治疗的疗效影响

Effects of Different Root Canal Irrigation Solutions on Root Canal Therapy in Patients with Chronic Pulpitis

目的:探究不同根管冲洗液对慢性牙髓炎患者根管治疗的疗效。方法:选取笔者医院2020年1月-2022年1月收治的108例慢性牙髓炎患者,分为对照组(54例)和研究组(54例),两组均行根管治疗,对照组采用次氯酸钠(NaClO)联合乙二胺四乙酸(Ethylene diamine tetraacetic acid,EDTA)冲洗,研究组则选用NaClO联合QMix冲洗,记录两组临床疗效,渗出液中基质金属蛋白酶-9(Matrix metalloproteinase 9,MMP-9)、基质金属蛋白酶-8(Matrix metalloproteinase 8,MMP-8)和基质金属蛋白酶-2(Matrix metalloproteinase 2,MMP-2)水平、炎性因子(IL-1β、IL-8以及TNF-α)、视觉模拟量表(Visual analogue scale,VAS)评分及不良反应发生情况。结果:治疗后,两组MMP-9、MMP-8、MMP-2和IL-1β、IL-8、TNF-α均下降,且研究组低于对照组(P<0.05),两组临床疗效、VAS评分与不良反应比较,差异无统计学意义(P>0.05)。结论:慢性牙髓炎患者根管治疗中采用NaClO联合QMix冲洗患牙,可减轻炎症反应,缓解疼痛,临床疗效显著。

Objective To explore the effect of different root canalflushing solution on the treatment of chronic pulpitis.Methods A total of 108 patients with chronic pulpitis admitted to the author's hospital from January 2020 to January 2022 were selected and divided into a control group(54 cases)and a study group(54 cases).Both groups were treated with root canal treatment.The control group was treated with sodium hypochlorite(NaClO)combined with ethylene diamine tetraacetic acid(EDTA)irrigation,and the study group was treated with NaClO combined with QMix irrigation.The clinical efficacy,the levels of matrix metalloproteinase 9(MMP-9),matrix metalloproteinase 8(MMP-8)and matrix metalloproteinase 2(MMP-2)in exudate,inflammatory factors(IL-1β,IL-8 and TNF-α),visual analogue scale(VAS)and adverse reactions were recorded in the two groups.Results After treatment,MMP-9,MMP-8,MMP-2 and IL-1β,IL-8 and TNF-αwere decreased in both groups,and the study group were lower than the control group(P<0.05).There were no significant difference in clinical efficacy,pain degree and adverse reactions between the two groups(P>0.05).Conclusion In the root canal treatment of patients with chronic pulpitis,using NaClO combined with QMix to wash the affected teeth can reduce inflammation and relieve pain,and the clinical effect is significant.