中间体2-氯-4-氟-5-硝基苯甲酸的新合成方法

Novel synthesis of the intermediate 2-chloro-4-fluoro-5-nitrobenzoic acid

探索中间体2-氯-4-氟-5-硝基苯甲酸的新合成方法。从4-氟苯胺出发,经过盐酸-双氧水体系氯化、重氮化、氰化、硝化-水解串联反应共4步得到2-氯-4-氟-5-硝基苯甲酸,纯度96.2%,总收率59.2%。新合成方法原材料易得、条件温和,具有工业化应用前景。

A new synthesis route of the intermediate 2-chloro-4-fluoro-5-nitrobenzoic acid was explored.Starting from 4-fluoroaniline,2-chloro-4-fluoro-5-nitrobenzoic acid was obtained by six steps,including oxidation-chlorination,diazo-cyanidation,nitration-hydrolysis,with a purity of 96.2%and an overall yield of 59.2%.The new synthesis method has the advantages of easily available raw materials and mild conditions,and is suitable for industrial production.