幼年型复发性呼吸道乳头状瘤病患者生长发育、智力水平及心理状态的临床观察

Clinical observation of growth and development,intellectual level,and psychological status in patients with juvenileonset recurrent respiratory papilloma

目的探讨幼年型复发性呼吸道乳头状瘤病(juvenile-onset recurrent respiratory papillomatosis,JORRP)对生长发育、智力水平及心理状态的影响。方法回顾性分析2023年1~12月就诊于首都医科大学附属北京同仁医院的40例JORRP患者(观察组)与同期体检的40名健康青少年(对照组)的临床资料。应用体重指数(BMI)、瑞文标准推理测验(Raven’s standard progressive matrices,SPM)、自我缺陷感量表(the feelings of inadequacy scale,FIS)评价入组人群的生长发育、智力水平及心理状态。结果观察组BMI为(21.320±3.609)kg/m²,对照组为(22.250±2.685)kg/m²,两组间差异无统计学意义(U=668.000,P>0.05)。SPM分数经过标准表换算后得出,观察组智力水平良好者占5%(2/40)、中等者占55%(22/40)、中下者占35%(14/40)、低下者占5%(2/40),对照组智力水平良好者占5%(2/40)、中等者占90%(36/40)、中下者占5%(2/40),两组间SPM总分、A组知觉辨别能力、D组系列关系能力及E组抽象推理能力得分差异有统计学意义(P<0.05),且两组智力水平均与生活地区相关(|r|>0.3,P<0.05)。观察组与对照组FIS分数差异有统计学意义(86.650±21.680 vs.62.250±9.446,U=270.000,P<0.001),且观察组的初次发病年龄与其自卑感呈负相关(|r|>0.3,P<0.05)。观察组手术次数与智力水平、FIS得分无相关性(|r|<0.3,P>0.05)。结论JORRP不影响患者的生长发育,但能在一定程度上增加患者的自卑感,对患者心理健康造成负面影响。

OBJECTIVE Exploring the effects of juvenile-onset recurrent respiratory papillomatosis on growth and development,intellectual level,and psychological status.METHODS The clinical data of 40 patients with JORRP who attended Beijing Tongren Hospital of Capital Medical University from January to December 2023(observation group)and 40 healthy adolescents who had medical checkups at the hospital during the same period(control group)were retrospectively analyzed.The body mass index(BMI),Raven's standard progressive matrices(SPM),and the feelings of inadequacy scale(FIS)were used to evaluate the growth and development,intelligence level,and psychological status of the enrolled population.RESULTS BMI was(21.320±3.609)kg/m²in the observation group and(22.250±2.685)kg/m²in the control group.The difference between the two groups was not statistically significant(U=668.000,P>0.05).According to the standard conversion of SPM scores,the proportion of observation group with good intelligence level was 5%(2/40),average level was 55%(22/40),below average level was 35%(14/40),and low level was 5%(2/40),while 5%(2/40)of the control group had good intelligence,90%(36/40)had average intelligence,and 5%(2/40)had below average intelligence.The differences in SPM total scores and scores of perceptual discrimination ability in group A,series relationship ability in group D and abstract reasoning ability in group E between the two groups were statistically significant(P<0.05).The intelligence levels of both groups were related to their living areas(|r|>0.3,P<0.05).The difference in FIS scores between the observation group and the control group was statistically significant(86.650±21.680 vs.62.250±9.446,U=270.000,P<0.001).The age of first onset in the observation group was negatively correlated with its sense of inferiority(|r|>0.3,P<0.05).There was no correlation between the number of surgeries in the observation group and their intelligence level and FIS scores(|r|<0.3,P>0.05).CONCLUSION JORRP does not affect the growth and development of patients,but can increase their sense of inferiority to a certain extent,which has a negative impact on their mental health.