肿瘤代谢重编程为胶质瘤治疗提供新靶点研究

Tumor Metabolism Reprogramming Provides Novel Targets for Glioblastoma Therapy

胶质瘤研究在近几十年取得极大进展,但对胶质瘤的治疗仍然没有有效的手段,患者预后效果仍然极差.代谢重编程是胶质瘤的重要标志,随着代谢组学技术的发展,更多受胶质瘤基因突变以及代谢环境调控的胞内代谢异常机制被发现,其中包括葡萄糖、脂质和氨基酸代谢.靶向因基因突变造成的代谢重编程通路,已成为特异性杀伤胶质瘤细胞的新途径.多种潜在的靶向药物已经投入研究,且在体内模型中展现了出色的疗效.本文就近年来胶质瘤代谢异常机制以及靶向药物的研究进展进行综述.

Glioma research has witnessed significant progress in recent decades,yet effective treatments for glio-blastoma remain elusive,leading to dismal prognoses for patients.Metabolic reprogramming stands out as a cru-cial hallmark of gliomas.With advancements in metabolic technologies,novel mechanisms of intracellular meta-bolic dysregulation,influenced by glioma gene mutations and metabolic microenvironmental control,are unveiled.These encompass alterations in glucose,lipid,and amino acid metabolism.Targeting metabolic path-ways regulated by genetic mutations has emerged as a promising avenue for selectively eradicating glioma cells.Several potential therapeutic agents are currently under investigation,demonstrating remarkable efficacy in in vivo models.This review provides a comprehensive overview of recent advances in understanding the mecha-nisms of metabolic abnormalities in gliomas and the advancements in targeted drug therapies for this challenging disease.