银杏叶提取物联合尿激酶经靶动脉灌注治疗血栓闭塞性脉管炎的临床研究

Clinical study of ginkgo biloba extract combined with urokinase in the treatment of thromboangiitis obliterans through target artery perfusion

目的探讨银杏叶提取物(GBE)联合尿激酶(URK)经靶动脉灌注治疗血栓闭塞性脉管炎(TAO)的有效性及安全性。方法选取2019年3月至2022年4月于十堰市太和医院收治的83例男性TAO患者为研究对象,采用随机数字表法将患者随机分为对照组(n=40,单一采用经靶动脉灌注GBE治疗)与研究组(n=43,在对照组基础上加用URK治疗方案),比较两组患者疼痛评分、间歇性跛行距离、血流动力学指标及不良反应发生情况。结果术后7、30、90 d,研究组患者疼痛评分、间歇性跛行距离评分均低于对照组患者,差异均有统计学意义(P﹤0.05)。术后7、30、90 d,研究组患者踝肱指数(ABI)、趾肱指数(TBI)均高于对照组患者,差异均有统计学意义(P﹤0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论GBE联合URK经靶动脉灌注治疗TAO患者较单用GBE可更显著改善患者的临床症状,提高患者的生活质量,但同时不会增加出血等不良反应风险,值得临床推广。

Objective To investigate the efficacy and safety of ginkgo biloba extract(GBE)combined with urokinase(URK)in the treatment of thromboangiitis obliterans(TAO)by target artery infusion.Method A total of 83 male patients with TAO admitted to Shiyan Taihe Hospital from March 2019 to April 2022 were selected as the study objects,they were randomly divided into control group(n=40,receiving targeted arterial perfusion GBE treatment alone)and study group(n=43,adding URK treatment to the control group)by using random number table method.The pain score,intermittent claudication distance,hemodynamic indexes and the occurrence of adverse reactions were compared between the two groups.Result The pain score and intermittent claudication distance score of the study group were lower than those of the control group at 7,30 and 90 d after surgery,the differences were statistically significant(P<0.05).The ankle-brachial index(ABI)and toe brachial index(TBI)in the study group were higher than those in the control group at 7,30 and 90 d after surgery,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Compared with GBE alone,GBE combined with URK through target artery perfusion can significantly improve the clinical symptoms and quality of life of TAO patients,but it does not increase the risk of adverse reactions such as bleeding,which is worthy of clinical promotion.