MTHFR、MTRR基因多态性与阻塞性睡眠呼吸暂停低通气综合征的研究进展

Advances in the Study of MTHFR and MTRR Gene Polymorphisms and OSAHS

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种可引起全身多系统功能紊乱的睡眠障碍性疾病,严重时可致死;同型半胱氨酸(Hcy)是一种含硫氨基酸,血浆Hcy水平与心血管疾病、高血压、炎症、癌症、代谢等密切相关;大量研究表明OSAHS可引起Hcy水平变化,Hcy与叶酸代谢的关键酶基因MTHFR、MTRR的研究可能为OSAHS与Hcy之间的相关性及可能的机制提供理论依据。系统地回顾国内外相关文献,主要就OSAHS对Hcy影响及MTHFR、MTRR作用和可能机制的研究现状作一综述,为将来OSAHS的研究提供进一步的理论根据。

Sleep apnea hypopnea syndrom(OSAHS)is a sleep disorder that can cause systemic multi-system dysfunction,and can be fatal in severe cases.Homocysteine(Hcy)is a sulfur-containing amino acid,Hcy level is closely related to cardiovascular disease,hypertension,inflammation,cancer,metabolism and so on.Numerous studies have shown that OSAHS can cause changes in Hcy levels,and the study of key enzyme genes MTHFR and MTRR related to folate metabolism may provide a theoretical basis for the correlation and possible mechanisms between OSAHS and Hcy.A systematic review of relevant literature both domestically and internationally is conducted,focusing on the current research status of the impact of OSAHS on Hcy,as well as the effects and possible mechanisms of MTHFR and MTRR,in order to provide further theoretical basis for future research on OSAHS.