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低分子肝素钙联合逐级加压弹力袜预防妇科恶性肿瘤患者术后下肢深静脉血栓的临床研究

Clinical study of low molecular weight heparin calcium combined with progressive compression stockings in the prevention of postoperative deep vein thrombosis in patients with gynecological malignant tumors
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摘要 目的探讨低分子肝素钙联合逐级加压弹力袜预防妇科恶性肿瘤患者术后下肢深静脉血栓(DVT)的临床效果。方法选取2022年1—12月于赣南医学院第一附属医院经外科手术治疗的180例妇科肿瘤患者作为研究对象,按照随机数字表法分为对照组与研究组,每组90例。对照组予低分子肝素钙进行常规治疗,研究组在对照组基础上联合逐级加压弹力袜治疗。比较两组血清学指标、凝血功能指标、血流速度、下肢周径及术后DVT发生情况。结果干预后,研究组血小板计数、纤维蛋白原、D-二聚体水平均低于对照组,差异有统计学意义(P<0.05)。干预后,研究组活化部分凝血活酶时间、凝血酶原时间、凝血酶时间均长于对照组,下肢血流峰速、血流平均速度均快于对照组,差异有统计学意义(P<0.05)。干预后,研究组下肢周径短于对照组,术后下肢DVT发生率低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素钙联合逐级加压弹力袜治疗经外科手术的妇科肿瘤患者,有助于预防术后DVT形成,改善机体血流状态,值得临床推广应用。 Objective To explore the clinical effect of low molecular weight heparin calcium combined with progressive compression stockings in the prevention of postoperative deep vein thrombosis(DVT)in patients with gynecological malignant tumors.Methods 180 patients with gyneco-logical tumor treated by surgery in the First Affiliated Hospital of Gannan Medical College from January to December 2022 were selected as the study subjects,they were divided into the control group and the study group according to random number table method,with 90 cases in each group.The control group received conventional treatment with low molecular weight heparin calcium,and the study group was combined with progressive com-pression stockings on the basis of the control group.The serological indexes,coagulation function indexes,blood flow velocity,lower extremity cir-cumference and postoperative DVT were compared between the two groups.Results After intervention,the platelet count,fibrinogen and D-dimer levels in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After intervention,the acti-vated partial thromboplastin time,prothrombin time and thrombin time in the study group were longer than those in the control group,and the lower extremity blood flow peak velocity and average blood flow velocity were faster than those in the control group,the differences were statistically signif-icant(P<0.05).After intervention,the lower extremity circumference diameter in the study group was shorter than that in the control group,and the incidence of postoperative DVT of the lower extremity was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion The low molecular weight heparin calcium combined with progressive compression stockings for gynecological tumor patients treated by surgery can help to prevent postoperative DVT of the lower extremities and improve the blood flow status of the body,which is worthy of promotion and application.
作者 廖爱红 郭雪华 罗艳 LIAO Aihong;GUO Xuehua;LUO Yan(Department of Gynecology,the First Affiliated Hospital of Gannan Medical College,Ganzhou,Jiangxi,341000,China)
出处 《当代医学》 2024年第6期77-80,共4页 Contemporary Medicine
基金 江西省卫生健康委科技计划项目(202210857)。
关键词 低分子肝素钙 逐级加压弹力袜 妇科患者 恶性肿瘤 下肢深静脉血栓 Low molecular weight heparin calcium Progressive compression stockings Gynecological patients Malignant tumor Lower ex-tremity deep vein thrombosis
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