复发性卵巢癌患者术后血清CA125、D-D水平及残留病灶大小对无瘤生存期的影响

Effects of Serum CA125,D-D Levels and Residual Lesion Size on Tumor-free Survival in Patients with Recurrent Ovarian Cancer After Surgery

目的 探讨复发性卵巢癌患者术后血清糖链抗原125(CA125)、D-二聚体(D-D)水平及残留病灶大小对无瘤生存期的影响。方法 回顾性分析50例复发性卵巢癌患者的临床资料,随访并记录无瘤生存期。统计患者一般资料及术后血清CA125、D-D水平,分析无瘤生存期影响因素;以Pearson相关系数分析术后CA125、D-D水平及残留病灶大小与无瘤生存期的相关性。结果 不同临床分期、分化程度、化疗疗程、CA125、D-D水平及残留病灶大小的患者无瘤生存期比较,差异有统计学意义(P<0.05);COX回归分析显示,术前临床分期、术后CA125水平、术后D-D水平及术后残留病灶大小是复发性卵巢癌患者无瘤生存期的独立影响因素(P<0.05);Pearson相关性分析显示,术后CA125、D-D水平及残留病灶大小与无瘤生存期均呈负相关(P<0.05)。结论 复发性卵巢癌患者术后CA125、D-D水平及残留病灶大小是影响其无瘤生存期的重要因素。

Objective To explore the effects of serum carbohydrate antigen 125(CA125),D-Dimer(D-D)levels and residual lesion size on tumor-free survival in patients with recurrent ovarian cancer after surgery.Methods The clinical data of 50 patients with recurrent ovarian cancer were retrospectively analyzed,and the disease-free survival time was followed up and recorded.General data and postoperative serum CA125 and D-D levels of patients were analyzed,factors influencing disease-free survival were analyzed.Pearson correlation coefficient was used to analyze the correlation between postoperative CA125,D-D levels,residual lesion size and tumor-free survival.Results Tumor free survival of patients with different clinical stage,differentiation degree,chemotherapy course,CA125,D-D level and residual lesion size were statistically significant(P<0.05).COX regression analysis showed that preoperative clinical stage,postoperative CA125 level,postoperative D-D level and postoperative residual lesion size were independent influencing factors for tumor free survival of patients with recurrent ovarian cancer(P<0.05).Pearson correlation analysis showed that postoperative CA125,D-D levels and residual lesion size were negatively correlated with tumor-free survival(P<0.05).Conclusion Postoperative CA125 and D-D levels and residual lesion size are important factors affecting tumor free survival in patients with recurrent ovarian cancer.