期刊文献+

输卵管阻塞性不孕患者血清TGF-β1、IL-2、MMP-9水平及临床意义

Levels of the serum transforming growth factor-β1, interleukin-2 and matrix metalloproteinase-9 of women with tubal obstructive infertility and their clinical significance
下载PDF
导出
摘要 目的:分析输卵管阻塞性不孕患者血清转化生长因子-β1(TGF-β1)、白细胞介素-2(IL-2)、基质金属蛋白酶-9(MMP-9)水平变化及临床意义。方法:以本院2022年3月-2023年10月诊治的60例输卵管阻塞性不孕患者为病例组,正常妊娠分娩的女性50例为对照组。测定对比两组血清TGF-β1、IL-2、MMP-9水平,Pearson相关性分析血清指标间相关性,受试者工作特征(ROC)曲线分析血清指标诊断不孕效能,logistic多因素回归分析输卵管阻塞性不孕发生影响因素。结果:病例组术前血清TGF-β1(593.79±148.23 ng/L)、IL-2(3.90±0.75 ng/L)、MMP-9(384.88±86.87 ng/ml)水平均高于对照组(239.42±113.37 ng/L、3.09±0.84 ng/L、178.98±80.85 ng/ml),术后血清TGF-β1、IL-2、MMP-9水平较术前均下降,血清TGF-β1与IL-2、MMP-9,及IL-2与MMP-9均呈正相关(均P<0.05)。ROC曲线分析,诊断不孕TGF-β1曲线下面积(AUC)0.941、敏感度88.3%、特异度94.0%,IL-2 AUC 0.778、敏感度66.7%、特异度84.0%,MMP-9 AUC 0.946、敏感度88.3%、特异度86.0%,3指标联合诊断AUC为0.992,敏感度93.3%、特异度100.0%。logistic回归分析,血清TGF-β1、IL-2、MMP-9异常升高是输卵管阻塞性不孕发发生的危险因素(均P<0.05)。结论:输卵管阻塞性不孕患者血清TGF-β1、IL-2、MMP-9水平均高表达,且是不孕发生的危险因素,3者联合检测对输卵管阻塞性不孕有较高诊断价值。 Objective:To analyze the levels changes of the serum transforming growth factor-β1(TGF-β1),interleukin-2(IL-2) and matrix metalloproteinase-9(MMP-9) of the women with tubal obstructive infertility,and to study their clinical significance.Methods:A total of 60 women with tubal obstructive infertility diagnosed and treated in the hospital were selected in study group and 50 women with normal pregnancy and delivery were selected in control group from March 2022 to October 2023.The serum TGF-β1,IL-2 and MMP-9 levels of the women were measured and compared between the two groups,and the carrelation among which was analyzed by Pearson correlation analysis.Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy of the serum TGF-β1,IL-2 and MMP-9levels of the women for their infertility,and the influencing factors of the tubal obstructive infertility of the women were analyzed by logistic multivariate regression.Results:The preoperative levels of the serum TGF-β1(593.79±148.23 ng/L),IL-2(3.90±0.75 ng/L) and MMP-9(384.88±36.87 ng/ml) of the women in the study group were significantly higher than those(239.42±113.37 ng/L,3.09±0.84 ng/L and 178.98±80.85 ng/ml) of the women in the control group.The levels of the serum TGF-β1,IL-2 and MMP-9 of the women after surgery were significantly lower than those before surgery,the serum TGF-β1 level of the women was positively correlated with their serum IL-2 and MMP-9 levels,and the serum IL-2 level of the women was positively correlated with their serum MMP-9 level(all P<0.05).ROC curve analysis showed that the area under curve(AUC),the sensitivity and the specificity of the TGF-β1 level of the women for diagnosing their infertility were 0.941,88.3% and 94.0%,respectively,which of the IL-2 level of the women for diagnosing their infertility were 0.778,66.7% and 84.0%,respectively,which of the MMP-9 level of the women for diagnosing their infertility were0.946,88.3% and 86.0%,respectively,and which of the combined levels of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility were 0.992,93.3% and 100.0%,respectively.Logistic regression analysis showed that the abnormal increasing serum TGF-β1,IL-2 and MMP-9 levels of the women were the risk factors of the infertility caused by fallopian tube obstruction of the women(all P<0.05).Conclusion:The levels of the serum TGF-β1,IL-2 and MMP-9 of the infertility women caused by fallopian tube obstruction are highly expressed,which are the risk factors of their infertility.The combined detections of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility has high value for their tubal obstructive infertility.
作者 张林风 王晓倩 彭媛媛 ZHANG Linfeng;WANG Xiaoqian;PENG Yuanyuan(The Second People's Hospital of Hengshui,Hengshui,Hebei Province,053000)
出处 《中国计划生育学杂志》 2024年第7期1621-1625,共5页 Chinese Journal of Family Planning
关键词 输卵管阻塞性不孕 转化生长因子-Β1 白细胞介素-2 基质金属蛋白酶-9 危险因素 相关性 诊断 Tubal obstructive infertility Transforming growth factor-β1 Interleukin-2 Matrix metalloproteinase-9 Risk factors Correlation Diagnosis
  • 引文网络
  • 相关文献

参考文献11

二级参考文献116

  • 1刘丽,袁孟珂,陈婧,王亚文,邓楠,孙一鸣.针药联合治疗输卵管炎性不孕症临床观察[J].辽宁中医药大学学报,2020(8):4-7. 被引量:9
  • 2乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2007:6
  • 3LUO L'WU S Z,CHEN X Q. Induced abortion amongunmarried women in sichuan province,China [J]. Contraception, 1995,51( 1 ) : 59-63.
  • 4LUTFJEBOER F Y,VERHOEEVE H R,VAN DESSEL H J, et al. The value of medical history taking as risk indicator for tuboperitoneal pathology: a systematic review [J]. Infect Dis Clin North Am, 2008,22(4 ):693.
  • 5TORRES-SANCHEZ L, LOPEZ-CARRILLO L, ESPIN- OZA H,et al. Is induced abortion a contributing factor to tubal infertility in Mexico Evidence from a ease control study [J]. BJOG,2004,111(1l):1254.
  • 6DALING J R,WEISS N S,VOIGT. Tubal infertility in relation to prior induced abortion [J]. Fertil Steril, 1985,43(3):389- 394.
  • 7PRICE M J, ADES A E, WELTON N J, et al. How much t- ubal factor infertility is caused by Chlamydia Estimates based on serological evidence corrected for sensitivity and specificity[ J]. Sex Transm Dis, 2012,39(8) : 608- 613.
  • 8BACZYNSKA A, FUNCH P, FEDDER J, et al. Morphology of human fallopian tubes after infection with mycoplasma genitalium and mycoplasma hominis- in vitro organ culture study [J]. Hum Reprod,2007,22(4):968.
  • 9李强,匡延平,杨慧琳,傅永伦,孙红,范莉萍,石海斌.输卵管栓塞术在体外受精-胚胎移植前处理输卵管积水中的应用[J].中华妇产科杂志,2008,43(6):414-417. 被引量:30
  • 10陈晓勤,刘莉,唐永军,雷贞武.人工流产与输卵管性不孕的危险[J].国际生殖健康/计划生育杂志,2009,28(1):59-61. 被引量:6

共引文献234

;
使用帮助 返回顶部