摘要
目的:分析输卵管阻塞性不孕患者血清转化生长因子-β1(TGF-β1)、白细胞介素-2(IL-2)、基质金属蛋白酶-9(MMP-9)水平变化及临床意义。方法:以本院2022年3月-2023年10月诊治的60例输卵管阻塞性不孕患者为病例组,正常妊娠分娩的女性50例为对照组。测定对比两组血清TGF-β1、IL-2、MMP-9水平,Pearson相关性分析血清指标间相关性,受试者工作特征(ROC)曲线分析血清指标诊断不孕效能,logistic多因素回归分析输卵管阻塞性不孕发生影响因素。结果:病例组术前血清TGF-β1(593.79±148.23 ng/L)、IL-2(3.90±0.75 ng/L)、MMP-9(384.88±86.87 ng/ml)水平均高于对照组(239.42±113.37 ng/L、3.09±0.84 ng/L、178.98±80.85 ng/ml),术后血清TGF-β1、IL-2、MMP-9水平较术前均下降,血清TGF-β1与IL-2、MMP-9,及IL-2与MMP-9均呈正相关(均P<0.05)。ROC曲线分析,诊断不孕TGF-β1曲线下面积(AUC)0.941、敏感度88.3%、特异度94.0%,IL-2 AUC 0.778、敏感度66.7%、特异度84.0%,MMP-9 AUC 0.946、敏感度88.3%、特异度86.0%,3指标联合诊断AUC为0.992,敏感度93.3%、特异度100.0%。logistic回归分析,血清TGF-β1、IL-2、MMP-9异常升高是输卵管阻塞性不孕发发生的危险因素(均P<0.05)。结论:输卵管阻塞性不孕患者血清TGF-β1、IL-2、MMP-9水平均高表达,且是不孕发生的危险因素,3者联合检测对输卵管阻塞性不孕有较高诊断价值。
Objective:To analyze the levels changes of the serum transforming growth factor-β1(TGF-β1),interleukin-2(IL-2) and matrix metalloproteinase-9(MMP-9) of the women with tubal obstructive infertility,and to study their clinical significance.Methods:A total of 60 women with tubal obstructive infertility diagnosed and treated in the hospital were selected in study group and 50 women with normal pregnancy and delivery were selected in control group from March 2022 to October 2023.The serum TGF-β1,IL-2 and MMP-9 levels of the women were measured and compared between the two groups,and the carrelation among which was analyzed by Pearson correlation analysis.Receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy of the serum TGF-β1,IL-2 and MMP-9levels of the women for their infertility,and the influencing factors of the tubal obstructive infertility of the women were analyzed by logistic multivariate regression.Results:The preoperative levels of the serum TGF-β1(593.79±148.23 ng/L),IL-2(3.90±0.75 ng/L) and MMP-9(384.88±36.87 ng/ml) of the women in the study group were significantly higher than those(239.42±113.37 ng/L,3.09±0.84 ng/L and 178.98±80.85 ng/ml) of the women in the control group.The levels of the serum TGF-β1,IL-2 and MMP-9 of the women after surgery were significantly lower than those before surgery,the serum TGF-β1 level of the women was positively correlated with their serum IL-2 and MMP-9 levels,and the serum IL-2 level of the women was positively correlated with their serum MMP-9 level(all P<0.05).ROC curve analysis showed that the area under curve(AUC),the sensitivity and the specificity of the TGF-β1 level of the women for diagnosing their infertility were 0.941,88.3% and 94.0%,respectively,which of the IL-2 level of the women for diagnosing their infertility were 0.778,66.7% and 84.0%,respectively,which of the MMP-9 level of the women for diagnosing their infertility were0.946,88.3% and 86.0%,respectively,and which of the combined levels of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility were 0.992,93.3% and 100.0%,respectively.Logistic regression analysis showed that the abnormal increasing serum TGF-β1,IL-2 and MMP-9 levels of the women were the risk factors of the infertility caused by fallopian tube obstruction of the women(all P<0.05).Conclusion:The levels of the serum TGF-β1,IL-2 and MMP-9 of the infertility women caused by fallopian tube obstruction are highly expressed,which are the risk factors of their infertility.The combined detections of the serum TGF-β1,IL-2 and MMP-9 of the women for diagnosing their infertility has high value for their tubal obstructive infertility.
作者
张林风
王晓倩
彭媛媛
ZHANG Linfeng;WANG Xiaoqian;PENG Yuanyuan(The Second People's Hospital of Hengshui,Hengshui,Hebei Province,053000)
出处
《中国计划生育学杂志》
2024年第7期1621-1625,共5页
Chinese Journal of Family Planning