血清肿瘤坏死因子-α、胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ、肿瘤标志物联合检测对胃癌的诊断价值分析

Diagnostic Value of Serum Tumor Necrosis Factor-α,PepsinogenⅠ,PepsinogenⅡand Tumor Markers in Gastric Cancer

目的:探讨血清肿瘤坏死因子-α(TNF-α)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、癌胚抗原(CEA)、糖类抗原72-4(CA72-4)联合检测对胃癌的诊断价值。方法:选取2020年3月—2023年3月中山大学附属第六医院收治的胃癌患者80例作为研究组,慢性萎缩性胃炎患者40例作为对照组。比较不同组别、胃癌病情进展者血清TNF-α、PGⅠ、PGⅡ、CEA、CA72-4水平。采用受试者工作特征曲线(ROC)分析各血清指标水平对胃癌的诊断价值。结果:研究组血清TNF-α、PGⅡ、CEA、CA72-4水平高于对照组,PGⅠ水平低于对照组,差异有统计学意义(P<0.05)。进展期胃癌患者血清TNF-α、PGⅡ、CEA、CA72-4水平高于早期胃癌患者,PGⅠ水平低于早期胃癌患者,差异有统计学意义(P<0.05)。以研究组80例患者为阳性样本,以对照组40例患者为阴性样本,五项联合诊断胃癌的ROC曲线下面积大于单项诊断,差异有统计学意义(P<0.05)。结论:胃癌患者血清TNF-α、PGⅡ、CEA、CA72-4呈高表达,而PGⅠ呈低表达,且与胃癌进展密切相关,联合检测其水平有助于提高胃癌诊断价值。

Objective:To investigate the diagnostic value of serum tumor necrosis factor-α(TNF-α),pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),carcinoembryonic antigen(CEA)and carbohydrate antigen 72-4(CA72-4)in gastric cancer.Methods:A total of eighty patients with gastric cancer admitted to the Sixth Affiliated Hospital of Sun Yat-sen University from March 2020 to March 2023 were selected as the study group and forty patients with chronic atrophic gastritis as the control group.The serum levels of TNF-α,PGⅠ,PGⅡ,CEA and CA72-4 were compared in different groups and patients with gastric cancer progression.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic value of serum indexes in gastric cancer.Results:The serum levels of TNF-α,PGⅡ,CEA and CA72-4 in the study group were higher than those in the control group,while the serum levels of PGⅠwere lower than those in the control group,with statistical significance(P<0.05);serum levels of TNF-α,PGⅡ,CEA and CA72-4 in advanced gastric cancer patients were higher than those in early gastric cancer patients,and PGⅠlevels were lower than those in early gastric cancer patients,the difference was statistically significant(P<0.05);with 80 patients in the study group as positive samples and 40 patients in the control group as negative samples,the area under the ROC curve of the combined diagnosis of gastric cancer was larger than that of the single diagnosis,and the difference was statistically significant(P<0.05).Conclusion:Serum expressions of TNF-α,PGⅡ,CEA and CA72-4 were high in patients with gastric cancer,while the expression of PGⅠwas low,which was closely related to the progression of gastric cancer.The combined detection in patients with gastric cancer was helpful to improve the diagnostic value of gastric cancer.