UBE2S在食管鳞状细胞癌组织中的表达及临床意义

The expression of UBE2S in esophageal squamous cell carcinoma and its clinical significance

目的:探讨食管鳞状细胞癌(ESCC)组织中UBE2S的表达及临床意义。方法:采用免疫组化SP法检测ESCC、上皮内瘤变中UBE2S的表达情况,分析其表达与ESCC患者临床病理特征的相关性及对预后的影响。结果:UBE2S在ESCC中的表达明显高于癌旁组织(P=0.035)。高级别上皮内瘤变(HIN)(P<0.001)及ESCC(P<0.001)的阳性率均高于瘤旁组织。HIN(P=0.016)及ESCC(P=0.008)的阳性率均高于低级别上皮内瘤变(LIN)。ESCC患者中UBE2S表达与种族有关(P<0.001),UBE2S表达与TP53(r=0.288,P<0.001)、Ki67(r=0.210,P=0.002)表达呈正相关。UBE2S表达是影响ESCC患者无进展生存期(P=0.005)和总生存期(P=0.005)的独立因素。结论:UBE2S高表达可能是ESCC患者不良预后的独立因素,而GEPIA上的UBE2S与ESCC预后无统计学意义,有待进一步研究。

Objective:To investigate the expression and clinical significance of UBE2S in esophageal squamous cell carcinoma(ESCC).Methods:The expression of UBE2S in ESCC and precancerous tissues were detected by Immunohistochemical SP,the correlations between its expression and clinicopathological features were analyzed.The effect of UBE2S expression on ESCC prognosis was investigated.Results:The expression of UBE2S in ESCC was significantly higher than that in adjacent tissues(P=0.035).The positive rates of high-grade intraepithelial neoplasia(HIN)(P<0.001)and ESCC(P<0.001)were higher than that in adjacent tissues.The positive rates of HIN(P=0.016)and ESCC(P=0.008)were higher than that in low-grade intraepithelial neoplasia(LIN).The expression of UBE2S in ESCC patients was related to race(P<0.001),and it was positively correlated with the expressions of TP53(r=0.288,P<0.001)and Ki67(r=0.210,P=0.002).The expression of UBE2S is an independent risk factor affecting progression-free survival(P=0.005)and overall survival(P=0.005)in patients with ESCC.Conclusion:The high expression of UBE2S may be an independent risk factor of poor prognosis in patients with ESCC.However,the prognosis of UBE2S and ESCC on GEPIA has no statistical significance,which needs further study.