α-硫辛酸联合依帕司他对2型糖尿病伴糖尿病周围神经病变患者肌电图、血清炎症因子及血流变学的影响

Effects ofα-lipoic acid combined with epalrestat on electromyography,serum inflammatory factors and hemorheology in type 2 diabetes mellitus and diabetes peripheral

目的探讨α-硫辛酸联合依帕司他治疗2型糖尿病(T2DM)伴糖尿病周围神经病变(DPN)患者的效果,并分析其对肌电图、血清炎症因子和血流变学指标的影响。方法按照随机数字表法将2021年9月至2023年9月广西科技大学第一附属医院收治的84例T2DM合并DPN患者分为对照组(给予依帕司他治疗)和观察组(给予α-硫辛酸联合依帕司他治疗),各42例。比较两组患者肌电图指标、炎症因子和血流变学指标。结果治疗后,两组患者正中和腓总神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV)水平均升高,且观察组均高于对照组(均P<0.05)。治疗后,两组患者超敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)水平均较治疗前降低,且观察组均低于对照组(P<0.05)。治疗后,两组患者全血高切黏度、全血低切黏度和血浆黏度均低于治疗前,且观察组均低于对照组(均P<0.05)。结论给予T2DM合并DPN患者α-硫辛酸联合依帕司他治疗的效果显著,可有效提高神经传导速度,抑制炎症反应,调节血流变学。

Objective To discuss the effect ofα-lipoic acid combined with epalrestat on patients with type 2 diabetes mellitus(T2DM)and diabetes peripheral neuropathy(DPN),and analyze its effects on electromyography,the serum inflammatory factors and hemorheological indicators.Methods According to random number table method,84 T2DM patients with DPN admitted to the First Affiliated Hospital of Guangxi University of Science and Technology from September 2021 to September 2023 were divided into control group(treated with epalrestat)and observation group(treated withα-lipoic acid and epalrestat),with 42 cases in each group.The indicators of electromyogram(EMG),inflammatory factors and hemorheology were compared between the two groups.Results After treatment,the motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)levels of median and common peroneal nerve in the two groups of patients increased,and the observation group were higher than the control group(allP<0.05).After treatment,The hypersensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)in two groups of patients were lower than before treatment,and the observation group were lower than the control group(allP<0.05).After treatment,whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity values in two groups of patients were lower than before treatment,and the observation group were lower than those in the control group(all P<0.05).Conclusionα-lipoic acid combined with epalrestat is effective in the treatment of T2DM and DPN patients,which can improve nerve conduction velocity,inhibit inflammatory response and regulate hemorheology.