针刺调节BDNF/TrkB信号通路改善中枢神经系统疾病的研究进展

Research Progress of Acupuncture in Improving Central Nervous System Diseases by Regulating BDNF/TrkB Signaling Pathway

BDNF/TrkB信号通路作为神经元生长、发育和突触可塑性的关键调节器,广泛参与中枢神经系统疾病的发生发展,如缺血性脑卒中、阿尔茨海默病、帕金森病和脊髓损伤等。研究表明针刺能调节BDNF/TrkB信号通路的活性,对以上疾病具有显著的治疗潜力,其作用机制与参与突触结构重塑,抑制神经细胞凋亡,促进神经发生和突触再生等有关。本文综述了BDNF/TrkB相关信号通路在中枢神经系统疾病中的作用以及针刺对该通路的调控机制,以期为临床治疗提供新思路。未来研究应深入探究针刺对BDNF/TrkB信号通路的精准调控,以开发更高效安全的治疗策略。

As a key regulator of neuronal growth,development and synaptic plasticity,BDNF/TrkB signaling pathway is widely involved in the occurrence and development of central nervous system diseases,such as ischemic stroke,Alzheimer's disease,Parkinson's disease and spinal cord injury.Studies have shown that acupuncture can regulate the activity of BDNF/TrkB signaling pathway,and has significant therapeutic potential for these diseases.Its mechanism of action is related to participating in synaptic remodeling,inhibiting neuronal apoptosis,and promoting neurogenesis or synaptic regeneration.This article reviews the role of BDNF/TrkB signaling pathway in central nervous system diseases and the regulation mechanism of acupuncture on this pathway,in order to provide new ideas for clinical treatment.Future studies should further explore the precise regulatory mechanism of acupuncture on BDNF/TrkB signaling pathway in order to develop more efficient and safe treatment strategies.