组蛋白乳酸化调控巨噬细胞功能促进炎症微环境修复的研究进展

Research progress in the regulation of macrophage function and promotion of inflammation microenvironment repaired by histone lactylation

组蛋白乳酸化修饰是一种快速动态的转录后修饰形式,在巨噬细胞极化和功能性转换中发挥着重要作用。巨噬细胞是免疫系统中最重要的细胞类型之一,其功能的改变可以影响整个免疫系统的活动,是炎症微环境中的重要细胞之一。炎症微环境是许多疾病发生、发展所必需的,而抗炎状态的持续存在以及在肿瘤微环境中的免疫逃逸都阻碍了疾病的好转和愈合,如何调节炎症微环境已成为治疗许多疾病的重要研究方向之一。本文回顾了组蛋白乳酸化的生化途径,对组蛋白乳酸化调控巨噬细胞功能来改善炎症微环境的机制进行综述,强调组蛋白乳酸化在维持生物体内环境稳态中的重要性及在疾病中的应用作用;讨论未来研究方向,旨在为基于组蛋白乳酸化的治疗策略提供科学方向。

Histone lactylation modification is a rapidly dynamic post-translational modification that plays an important role in macrophage polarization and functional transformation.Macrophages are one of the most important cell types in the immune system,and changes in their function can affect the activity of the entire immune system.They are also important cells in the inflammatory microenvironment.The inflammatory microenvironment is necessary for the occurrence and development of many diseases,while the continuous existence of an anti-inflammatory state and immune escape in the tumor microenvironment hinder the improvement and healing of diseases.Therefore,how to regulate the inflammatory microenvironment has become an important research direction for the treatment of many diseases.This article reviews the biochemical pathways of histone lactylation and provides an overview of the mechanisms by which histone lactylation regulates macrophage function to improve the inflammatory microenvironment.It emphasizes the importance of histone lactylation in maintaining homeostasis in organisms and its potential applications in diseases.Finally,we discussed future research directions aimed at revealing the precise regulatory mechanisms of lactylation and providing scientific basis for lactylation-based treatment strategies.