早孕期子宫动脉搏动指数联合胎盘生长因子和平均动脉压对预测子痫前期的价值研究

Investigation of the Predictive Value of Early Pregnancy Uterine Artery Pulsatility Index in Combination with Placental Growth Factor and Mean Arterial Pressure for Preeclampsia

目的:研究早孕期子宫动脉搏动指数(UTPI)联合胎盘生长因子(PLGF)和平均动脉压(MAP)对预测产妇子痫前期(PE)的应用价值。方法:以本院确诊收治的70例PE产妇为研究组,另选同期体检健康产妇70例为对照组,两组均检测其早孕期UTPI、PLGF和MAP。结果:研究组早孕期UTPI和MAP水平均高于对照组,PLGF水平低于对照组,同时三项指标的联合测定对PE诊断的敏感度、准确度和特异度均高于任一单项检测(P<0.05)。结论:在产妇子痫前期的早期预测诊断中,早孕期的UTPI、PLGF和MAP联合检测能够进一步明确病症的病理特点,同时判断病变程度和病变趋势,进而为病症临床诊断、鉴别、预防和干预提供依据。

Objective:To explore the combined application value of uterine artery pulsatility index(UTPI)during early pregnancy,placental growth factor(PLGF),and mean arterial pressure(MAP)in predicting preeclampsia(PE)in pregnant women.Methods:This study included 70 pregnant women diagnosed with PE as the research group and 70 healthy pregnant women from the same period as the control group.UTPI,PLGF,and MAP were measured during the early pregnancy phase for both groups.Results:The research group exhibited higher levels of UTPI and MAP during the early pregnancy phase compared to the control group,and a lower PLGF level.Notably,the combined measurement of these three indices significantly improved the sensitivity,accuracy,and specificity for diagnosing PE over individual assessments(P<0.05).Conclusion:The concurrent evaluation of UTPI,PLGF,and MAP in early pregnancy enhances understanding of the pathophysiological characteristics of PE,facilitating the determination of disease severity and progression trends.This multi-parametric approach provides a robust basis for clinical diagnosis,differentiation,prevention,and intervention strategies in managing PE.