天麻钩藤汤加减联合依那普利叶酸片对原发性高血压患者血压水平与中医证候积分的影响

Effects of Modified Tianma Gouteng Decoction Combined with Enalapril Folic Acid Tablet on Blood Pressure Level and Traditional Chinese Medicine Syndrome Score in Patients with Essential Hypertension

目的 探讨天麻钩藤汤加减方联合依那普利叶酸片对原发性高血压患者血压水平、中医证候积分及椎动脉血流动力学指标的影响。方法 选取宜都市中医医院于2022年11月—2023年11月收治的92例原发性高血压患者为研究对象,通过随机数表法分为两组,各46例。对照组采用依那普利与叶酸片进行治疗,观察组在对照组基础上加用天麻钩藤汤加减治疗,对比两组患者的血压水平、中医证候积分和椎动脉血流动力学指标。结果 治疗后,两组患者的血压均下降;研究组的平均舒张压为(77.25±2.87)mmHg,收缩压为(124.50±4.30)mmHg,均低于对照组的(85.74±3.52)mmHg、(131.75±3.91)mmHg,差异有统计学意义(t=12.678、8.461,P均<0.05)。两组的头痛、眩晕、心悸等中医证候积分均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。两组患者的椎动脉血流动力学指标均改善,且观察组患者血流峰值流速、舒张末期流速高于对照组,脉动指数水平低于对照组,差异有统计学意义(P均<0.05)。结论 天麻钩藤汤加减方与依那普利叶酸片联用治疗原发性高血压,能更有效降低血压和中医证候积分,优化椎动脉血流动力学指标。

Objective To investigate the effects of modified Tianma Guteng Decoction combined with enalapril folic acid tablet on blood pressure level,traditional Chinese medicine syndrome score and vertebral artery hemodynamics in patients with essential hypertension.Methods A total of 92 patients with essential hypertension admitted to Yidu Hospital of Traditional Chinese Medicine from November 2022 to November 2023were selected as the study objects.By random number table method,they were divided into two groups,46 cases each.The control group received enalapril folic acid tablets,while the observation group was treated with modified Tianma Gouteng decoction.Compared blood pressure levels,traditional Chinese medicine symptom scores,and vertebral artery hemodynamic indices between the two groups.Results After treatment,the blood pressure of both groups decreased,and the mean diastolic blood pressure of the study group was(77.25±2.87) mmHg and systolic blood pressure was(124.50±4.30) mmHg,which were lower than those of the control group(85.74±3.52) mmHg and(131.75±3.91) mmHg,the difference was statistically significant(t=12.678,8.461,both P<0.05).The scores of TCM syndromes such as headache,vertigo and palpitation were decreased in both groups,and the observation group was lower than the control group,the difference was statistically significant(all P<0.05).The vertebral artery hemodynamic indexes of the two groups were improved,and the peak blood flow velocity and end-diastolic flow velocity of the observation group were higher than those of the control group,and the pulsatility index level was lower than that of the control group,and the differences were statistically significant(all P<0.05).Conclusion Tianma Guteng Decoction combined and enalapril folic acid tablets in the treatment of essential hypertension can more effectively reduce blood pressure and TCM syndrome scores,and optimize vertebral artery hemodynamics indicators.