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BMI指数与老年CHF患者血浆Cys-C、NT-proBNP相关性及评测预后的可行性研究

Study on correlation between BMI index and plasma Cys-C and NT proBNP levels in elderly CHF patients and feasibility of prognosis assessment
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摘要 目的分析体质量指数(Body mass index,BMI)与老年慢性心力衰竭(Chronic heart failure,CHF)患者血浆胱抑素C(cystatinC,Cys-C)、N末端B型利钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)水平相关性,并分析血浆Cys-C、NT-proBNP评估老年CHF患者预后价值。方法选择2021年7月—2022年10月在本院接受治疗的192例老年慢性心力衰竭(CHF)患者作为研究对象,按照BMI指数分为肥胖组(49例)、超重组(68例)和正常组(75例)三组。对比各亚组患者血浆Cys-C、NT-proBNP水平差异,采用Pearson相关性分析的方式探究老年CHF患者BMI指数与血浆Cys-C、NT-proBNP相关性,对入组患者实施12个月随访,将患者按照预后情况区分为死亡组和存活组,对比两亚组患者血浆Cys-C、NT-proBNP水平差异并评估预后评估价值。结果肥胖组患者血浆Cys-C、NT-proBNP水平高于超重组,超重组患者血浆Cys-C、NT-proBNP水平高于正常组,差异具有统计学意义(P<0.05);入组老年CHF患者的BMI指数与其血浆Cys-C、NT-proBN水平均呈现明显的正相关性(r=0.7104,P<0.0001)(r=0.6603,P<0.0001);随访12个月显示,死亡组患者的血浆Cys-C、NT-proBNP水平显著高于存活组患者,差异具有统计学意义(P<0.05);血浆Cys-C、NT-proBNP对老年CHF预后评估曲线下面积(area under curv,AUC)为0.6930(P=0.0009)、0.7982(P<0.0001)。结论老年CHF患者随BMI指数升高,血浆Cys-C、NT-proBNP水平逐渐升高,血浆Cys-C、NT-proBNP对老年CHF临床结局具有一定的预测价值,进一步研究有推广应用于老年CHF预后评估潜力。 Objective To analyze the correlation between Body mass index(BMI)and plasma cystatin C(Cys-C)and N-terminal pro-b-type natural peptide(NT-proBNP)level in elderly patients with Chronic heart failure(CHF),and to analyze the value of plasma Cys-C and NT-proBNP in evaluating the prognosis of patients suffering from CHF.Methods 192 elderly patients suffering from CHF who were treated in the hospital from July 2021 to October 2022 were selected as the research objects,and the patients were divided into the normal group(n=75),the overweight group(68)and the obesity group(n=49)according to BMI index.The differences of plasma Cys-C and NT-proBNP levels in each subgroup were compared.Pearson correlation analysis was used to explore the correlation between BMI index and plasma Cys-C and NT-proBNP level in elderly patients with CHF.The patients were followed up for 12 months,and the patients were divided into the death group and the survival group according to their prognosis.The differences of plasma Cys-C and NT-proBNP levels between the two subgroups were compared and the prognostic evaluation value was evaluated.Results The plasma levels of Cys-C and NT proBNP in the obesity group were higher than those in the overweight group,and the plasma levels of Cys-C and NT proBNP in the super recombinant group were higher than those in the normal group(P<0.05).The BMI index of elderly patients with CHF was positively correlated with their plasma Cys-C and NT-proBN levels(r=0.7104,P<0.0001;r=0.6603,P<0.0001).The results of follow-up for 12 months showed that the levels of plasma Cys-C and NT-proBNP in the elderly patients with CHF who died were significantly higher than those in the surviving group(P<0.05).The area under curve(AUC)of plasma Cys-C and NT-proBNP in evaluating the prognosis of senile patients with CHF was 0.6930(P=0.0009)and 0.7982(P<0.0001).Conclusions With the increase of BMI index,the levels of plasma Cys-C and NT-proBNP in elderly patients with CHF gradually increased.Plasma Cys-C and NT-proBNP level have certain predictive value for the clinical outcome of the elderly patients with CHF,and they have the potential to be applied to the prognosis evaluation of the elderly patients with CHF after further research.
作者 王姣 郎月 耿直 Wang Jiao;Lang Yue;Geng Zhi(Department of Geriatrics,Jiaozuo People's Hospital,Jiaozuo,Henan 454000,China)
出处 《齐齐哈尔医学院学报》 2024年第15期1423-1426,共4页 Journal of Qiqihar Medical University
关键词 体质量指数 慢性心力衰竭 胱抑素C N末端B型利钠肽原 相关性 预后评估 Body mass index Chronic heart failure Cystatin c N-terminal b-type natriuretic peptide Relevance Prognostic evaluation
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