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中性粒细胞与HDL-C比值和单核细胞与HDL-C比值对冠状动脉狭窄程度的预测价值

Predictive value of neutrophil-to-HDL-C ratio and monocyte-to-HDL-C ratio for degree of coronary stenosis
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摘要 目的:分析中性粒细胞与高密度脂蛋白胆固醇比值(NHR)和单核细胞与高密度脂蛋白胆固醇比值(MHR)对冠状动脉狭窄程度的预测价值。方法:回顾性分析2021年10月至2022年4月于本院心内科住院行冠脉造影的患者273例。根据冠脉造影结果分为冠脉正常组89例,轻中度病变组(0<Gensini积分≤40分)97例、重度病变组(Gensini积分>40分)87例。比较三组患者的NHR和MHR。采用ROC曲线分析NHR和MHR对冠脉狭窄程度的预测价值。结果:与冠脉正常组相比,轻中度病变组和重度病变组的MHR[0.35(0.27,0.43)比0.49(0.34,0.64)比0.47(0.35,0.63)]、NHR[3.63(3.01,4.76)比4.91(3.77,6.52)比5.86(4.65,7.98)]均显著增加(P均<0.001);且重度病变组NHR值显著高于轻中度病变组(P=0.022)。ROC曲线分析提示,NHR预测轻中度和重度病变的曲线下面积(AUC)分别为0.723(95%CI:0.651~0.795)、0.820(95%CI:0.757~0.882);MHR预测轻中度和重度病变的AUC分别为0.689(95%CI:0.612~0.766)、0.706(95%CI:.0.628~0.882)。结论:NHR、MHR对冠脉动脉狭窄严重程度有较强的预测价值,并随着狭窄程度越严重,其预测价值越大。 Objective:To analyze the predictive value of neutrophil-to-high density lipoprotein cholesterol ratio(NHR)and monocyte-to-high density lipoprotein cholesterol ratio(MHR)for degree of coronary stenosis.Methods:A retrospective analysis was performed on 273 patients who underwent coronary angiography(CAG)and admitted in the Department of Cardiology of our hospital from October 2021 to April 2022.According to CAG results,they were divided into normal coronary group(n=89),mild-moderate disease group(n=97,0<Gensini score≤40 points)and severe disease group(n=87,Gensini score>40 points).NHR and MHR were compared among three groups.ROC curve was used to analyze predictive value of NHR and MHR for degree of coronary stenosis.Results:Compared with normal coronary group,there were significant rise in MHR[0.35(0.27,0.43)vs.0.49(0.34,0.64)vs.0.47(0.35,0.63)]and NHR[3.63(3.01,4.76)vs.4.91(3.77,6.52)vs.5.86(4.65,7.98)]in mild-moderate disease group and severe disease group(P<0.001 all),and NHR in severe disease group was significantly higher than that of mild-moderate disease group(P=0.022).ROC curve indicated that area under the curve(AUC)of NHR predicting mild-moderate disease and severe disease was 0.723(95%CI:0.651~0.795)and 0.820(95%CI:0.757~0.882)respectively;and AUC of MHR predicting mild-moderate disease and severe disease was 0.689(95%CI:0.612~0.766)and 0.706(95%CI:.0.628~0.882)respectively.Conclusion:NHR and MHR have strong predictive value for the severity of coronary artery stenosis,and the predictive value increases as the stenotic degree aggravates.
作者 靳佳丽 马静 梁甜 王玲 JIN Jia-li;MA Jing;LIANG Tian;WANG Ling(Department of Cardiology,First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)
出处 《心血管康复医学杂志》 CAS 2024年第4期471-475,共5页 Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词 冠状动脉狭窄 中性白细胞 单核细胞 脂蛋白类 HDL Coronary stenosis Neutrophils Monocytes Lipoproteins,HDL
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