超声血流参数联合胎盘生长因子预测分娩小于胎龄儿价值

The value of ultrasound blood flow parameters combined with placental growth factor in predicting the delivery of small for gestational age infants

目的:探讨超声血流参数联合胎盘生长因子(PLGF)对分娩小于胎龄儿的预测价值。方法:回顾性分析分娩小于胎龄儿孕妇120例临床资料(观察组),并选取同期分娩正常胎儿孕妇120名作为对照组,比较2组超声参数和PLGF水平,并分析超声参数联合PLGF对小于胎龄儿的预测价值。结果:观察组脐动脉血流搏动指数(PI)、阻力指数(RI)、收缩期与舒张期流速比(S/D)和静脉导管(DV)血流量均明显高于对照组(P<0.01),脐静脉(UV)血流量、血清PLGF水平均明显低于对照组(P<0.01)。ROC曲线分析显示,PI、RI、S/D、DV血流量、UV血流量、PLGF和上述指标联合检测预测分娩小于胎龄儿AUC分别为0.735、0.743、0.785、0.739、0.713、0.752、0.987。结论:分娩小于胎龄儿孕妇脐动脉PI、RI、S/D、DV血流量、UV血流量发生明显变化,且血清PLGF降低,超声血流参数联合血清PLGF可提高对分娩小于胎龄儿预测价值。

Objective:To investigate the predictive value of ultrasound blood flow parameters combined with placental growth factor(PLGF)in the delivery of small for gestational age infants.Methods:The clinical data of 120 pregnant women who delivered small for gestational age infants(observation group)were retrospectively analyzed,and 120 pregnant women who delivered normal fetuses at the same time were selected as the control group.The ultrasound parameters and PLGF levels between two groups were compared,and the predictive value of ultrasound parameters combined with PLGF for small for gestational age infants was analyzed.Results:The pulsatile index(PI),resistance index(RI),systolic to diastolic flow velocity ratio(S/D)and venous catheter(DV)blood flow of umbilical artery in the observation group were higher than those in control group(P<0.05),while the umbilical vein(UV)blood flow and serum PLGF in the observation group were lower than those in control group(P<0.05).The results of ROC curve showed that the AUC of PI,RI,S/D,DV blood flow,UV blood flow,PLGF and combined detection in predicting the delivery of SGA infants were 0.735,0.743,0.785,0.739,0.713,0.752,and 0.987,respectively.Conclusions:The umbilical artery PI,RI,S/D,DV blood flow and UV blood flow of pregnant women delivering small for gestational age infants change significantly,and the serum PLGF decreases.The ultrasound blood flow parameters combined with serum PLGF can improve the predictive value of the delivery of small for gestational age infants.