基于调控免疫炎症微血管损伤的补气活血法治疗肺炎“瘥后防复”思路的提出

Idea for Preventing Recurrence of Pneumonia by Invigorating Qi and Activating Blood Circulation Method Based on Regulation of Immune Inflammation and Microvascular Damage

肺炎恢复期后遗症严重影响患者身心健康,存在二次感染的风险,且与基础病相互影响导致恶性循环。做好肺炎恢复期康复工作,减少后遗症并预防反复发作是疾病防治的首选。研究显示肺炎长期后遗症和反复发作的机制可能与持续的机体免疫抑制和全身微炎症状态及微血管损伤有关。团队根据传统中医理论,结合长期临床与基础研究,提出“气虚血瘀”是肺炎恢复期的核心病机。因此,团队提出补气活血法治疗肺炎“瘥后防复”的机制与调控免疫炎症微血管损伤有关,调控T淋巴细胞紊乱提高免疫、抑制炎症因子改善机体微炎症状态和抗氧化保护内皮细胞调控微血管损伤,阐明其内在机制将为中医药治疗呼吸系统重大感染性疾病提供理论依据,传承精华、守正创新。

Sequelae during the recovery period of pneumonia seriously affect the physical and mental health of patients.There is a risk of secondary infection,and the interaction with the underlying diseases leads to a vicious circle.Managing the recovery period of pneumonia,reducing sequelae and preventing the recurrent attacks is the first choice for disease prevention and treatment.Studies have shown that the mechanism of long-term sequelae and recurrent episodes of pneumonia may be related to persistent immune suppression,systemic micro-inflammation and microvascular injury.The team put forward“Qi deficiency and blood stasis”is the core pathogenesis of convalescent period of pneumonia according to the theory of traditional Chinese medicine,combined with the long-term clinical and basic research.Therefore,the team has proposed that the mechanism of the method of invigorating Qi and activating blood circulation in the treatment of“preventing recurrence”of pneumonia is related to regulating the damage of immune inflammatory microvessels,regulating the disorder of T lymphocytes to improve immunity,inhibiting inflammatory factors to improve the state of micro inflammation of the body and antioxidant protection of endothelial cells to regulate the damage of microvessels.Clarifying its internal mechanism will provide theoretical basis for the treatment of major infectious diseases of the respiratory system by traditional Chinese medicine,inheriting the essence,maintaining the integrity and innovating.