Glucose-sensitive Membrane with PBA-based Contraction-type Linear Polymer as Chemical Valves Prepared by Surface Grafting

Glucose-sensitive membrane has potential application in self-regulating insulin release.Phenylboronic acid(PBA)is a well-known glucose reporter.Unfortunately,most PBA-based glucose-sensitive materials are expansion-type,which are not suitable as chemical valves in membrane pores for self-regulating insulin release.According to a new glucose-sensitive mechanism,we synthesized PBA-based contraction-type glucose-sensitive liner polymer and microgels.Herein,a glucose-sensitive membrane was prepared by grafting PBA-based contraction-type glucose-sensitive linear polymer on the membrane surface.Through adjusting the chain length and chain density,the glucose-sensitivity of the membrane was optimized.The membrane can reversibly regulate insulin release at physiologically relevant glucose concentrations in simulates body fluids and fetal bovine serum.The membrane also has good stability,anti-fouling and biocom patibility.It has potential application in selfregulating insulin release.