摘要
目的:探讨磁共振T_(2)^(*)mapping序列联合纹理特征参数在诊断女性绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)中的应用价值。方法:回顾性分析2019年3月至2021年4月某院收治的50例PMOP患者(作为骨质疏松组)的临床资料,另选择50例绝经后骨量正常(骨密度>120 mg/cm^(3))的体检者为骨量正常组和50例绝经后骨量减少(80 mg/cm^(3)<骨密度<120 mg/cm^(3))者为骨量减少组。3组均行磁共振腰椎常规序列及T_(2)^(*)mapping扫描,提取图像纹理特征。对比3组腰椎T_(2)^(*)值及纹理特征参数(能量、对比、相关、逆差距及熵),采用Spearman相关性分析腰椎T_(2)^(*)值、纹理特征参数与女性发生POMP的相关性,通过多因素Logistics回归分析确定女性发生PMOP的独立预测因子,采用ROC曲线分析T_(2)^(*)mapping序列联合纹理特征参数对PMOP的诊断效能,构建发生POMP的列线图预测模型并对模型进行验证。结果:3组腰椎T_(2)^(*)值、能量、对比、相关、逆差距及熵比较,差异有统计学意义(P<0.05)。Spearman相关分析结果显示,腰椎T_(2)^(*)值、对比及熵与发生POMP呈显著正相关关系,能量、相关及逆差距与发生POMP呈显著负相关关系(P<0.05)。T_(2)^(*)值、能量、对比、相关、逆差距及熵均为POMP发生的独立预测因子(P<0.05)。T_(2)^(*)mapping序列联合纹理特征参数诊断的AUC、敏感度及特异度均优于单项参数诊断。列线图预测模型预测女性发生POMP的概率为75.00%,经验证模型具有较高的区分度、校准能力和净获益率。结论:磁共振T_(2)^(*)mapping序列联合纹理特征参数对女性发生POMP的诊断效能良好,T_(2)^(*)值、能量、对比、相关、逆差距及熵可作为临床筛选POMP高危人群的敏感指标。
Objective To explore the application value of T_(2)^(*)mapping sequence combined with texture feature indicatoror in the diagnosis of postmenopausal osteoporosis(PMOP)in women.Methods The clinical data of 50 PMOP patients admitted to some hospital from March 2019 to April 2021(enrolled into an osteoporosis group)were analyzed retrospectively,and another two groups were established including a normal bone mineral density(BMD)group composed of 50 postmenopausal physical examiners with normal BMD(BMD>120 mg/cm^(3))and a reduced BMD group consisting of 50 postmenopausal women with decreased BMD(80 mg/cm^(3)<BMD<120 mg/cm^(3)).All the 3 groups underwent magnetic resonance lumbar spine conventional sequence and T_(2)^(*)mapping scanning and image texture feature extraction,which were compared in terms of lumbar T_(2)^(*)value and texture feature indicators including energy,contrast,correlation,deficit distance and entropy.Spearman correlation analysis was used to analyze the correlation between lumbar spine T_(2)^(*)values,texture feature indicators and the occurrence of POMP in women,independent predictors of the occurrence of PMOP in women were determined by multifactorial logistic regression analysis,the diagnostic efficacy of T_(2)^(*)mapping sequence combined with texture feature indicatoror for PMOP was analyzed using ROC curves,and a column-line diagram prediction model for POMP occurrence was constructed and validated.Results There were significant differences in T_(2)^(*)value,energy,contrast,correlation,deficit distance and entropy among the groups(P<0.05).Spearman correlation analysis showed that with the occurrence of POMP lumbar spine T_(2)^(*)value,contrast and entropy were significantly positively correlated,while energy,correlation and deficit distance were significantly negatively correlated(P<0.05).T_(2)^(*)value,energy,contrast,correlation,deficit distance and entropy were all independent predictors of the occurrence of POMP(P<0.05).T_(2)^(*)mapping sequence combined with texture feature indicatoror behaved better than any single indicator in AUC,sensitivity and specificity.The column-line diagram prediction model predicted a 75.00%probability of POMP in women,which was validated with advantages in discrimination,calibration and net benefit rate.Conclusion Magnetic resonance T_(2)^(*)mapping sequence combined with texture feature indicator behaves well in diagnosing POMP of women,and T_(2)^(*)value,energy,contrast,correlation,deficit distance and entropy can be used as sensitive indicators for clinical screening of people at high risk for POMP.
作者
杨小胜
李茂庭
李艳宁
刘松鹤
YANG Xiao-sheng;LI Mao-ting;LI Yan-ning;LIU Song-he(Department of Spinal Surgery,General Aviation Hospital,Beijing 100012,China)
出处
《医疗卫生装备》
CAS
2024年第8期68-72,共5页
Chinese Medical Equipment Journal