摘要
目的:观察头穴针刺联合密集训练对孤独症谱系障碍(ASD)患儿核心症状及血清5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)的影响。方法:将ASD患儿102例按随机数字表法分为对照组和治疗组各51例。对照组采取常规密集训练治疗,治疗组在对照组基础上联合头穴针刺治疗。比较2组治疗前后孤独症行为(ABC)、儿童孤独症评定量表(CARS)、孤独症治疗评估量表(ATEC)和父母育儿压力指数简表(PSI-SF)评分,以及血清5-HT、BDNF水平。结果:治疗后,2组ABC、CARS、ATEC评分均治疗前降低(P<0.05),且治疗组ABC、CARS、ATEC评分均低于对照组(P<0.05)。治疗后,2组感觉能力、交往能力、躯体运动能力、语言能力和自我照顾能力等ABC量表中各因子评分均较治疗前降低(P<0.05),且治疗组上述各项评分均低于对照组(P<0.05)。治疗后,2组PSI-SF总分及育儿愁苦、亲子互动失调、困难儿童3个维度评分均较治疗前降低(P<0.05),且治疗组上述各项评分均低于对照组(P<0.05)。治疗后,2组血清5-HT水平较治疗前降低(P<0.05),BDNF水平较治疗前升高(P<0.05);且治疗组5-HT水平低于对照组(P<0.05),BDNF水平高于对照组(P<0.05)。结论:头穴针刺联合密集训练能有效调节血清5-HT、BDNF水平,改善ASD患儿的核心症状,减轻父母育儿压力,提高整体治疗效果。
Objective:To observe the effect of the therapy of scalp point acupuncture combined with intensive training on core symptoms,serum 5-hydroxytryptamine(5-HT)and brain-derived neurotrophic factor(BDNF)of children with autism spectrum disorder(ASD).Methods:A total of 102 ASD children were divided into the control group and the treatment group according to the random number table method,with 51 cases in each group.The control group was treated with routine intensive training,and the treatment group was additionally treated with scalp point acupuncture based on the treatment of the control group.The scores of Autism Behavior Checklist(ABC),Childhood Autism Rating Scale(CARS),Autism Treatment Evaluation Checklist(ATEC)and Parenting Stress Index-Short Form(PSI-SF),and the levels of serum 5-HT and BDNF were compared before and after treatment between the two groups.Results:After treatment,the scores of ABC,CARS and ATEC in the two groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the scores of sensory,relating,body and object use,language and social and self-care in ABC index in the two groups were decreased when compared with those before treatment(P<0.05),and the above five scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the total PSI-SF scores,and scores of parental distress,parent-child dysfunctional interaction and difficult child in the two groups were decreased when compared with those before treatment(P<0.05),and the above four scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the serum 5-HT levels in the two groups were decreased when compared with those before treatment(P<0.05),and the serum BDNF levels were increased when compared with those before treatment(P<0.05);the serum 5-HT level in the treatment group was lower than that in the control group(P<0.05),and the serum BDNF level was higher than that in the control group(P<0.05).Conclusion:The therapy of scalp point acupuncture combined with intensive training can effectively regulate the levels of 5-HT and BDNF,improve the core symptoms of ASD children,reduce the parental pressure and enhance the overall curative effect.
作者
黄平香
赵志龙
毛平安
王法明
HUANG Pingxiang;ZHAO Zhilong;MAO Ping'an;WANG Faming(Department of Rehabilitation,Lishui People's Hospital,Lishui Zhejiang 323000,China)
出处
《新中医》
CAS
2024年第16期101-105,共5页
New Chinese Medicine
关键词
孤独症谱系障碍
儿童
头穴针刺
密集训练
核心症状
5-羟色胺
脑腺性神经营养因子
Autism spectrum disorder
Children
Scalp point acupuncture
Intensive training
Core symptoms
5-hydroxytryptamine
Brain-derived neurotrophic factor